Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IX21 / SLF2_HUMAN
Protein Name SMC5-SMC6 complex localization factor protein 2
Gene Name Name: SLF2
Synonyms:C10orf6,FAM178A;
Organism Homo sapiens (Human)

PRO ID PR:Q8IX21
DAG View
PRO Name SMC5-SMC6 complex localization factor protein 2 (human)
Definition An SMC5-SMC6 complex localization factor protein 2 that is encoded in the genome of human.
Short Label hSLF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IX21 (SLF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
T400 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus   UniProt 23186163
S484 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
T551 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus   UniProt 21406692
S607 Phosphorylation PhosphoSitePlus   UniProt 21406692
S614 Phosphorylation PhosphoSitePlus   UniProt 21406692
K647 Ubiquitination PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
S701 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S710 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K903 Ubiquitination PhosphoSitePlus
S1018 Phosphorylation PhosphoSitePlus
K1024 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S444 Phosphorylation HPRD 17525332, 18077418
S701 Phosphorylation HPRD 18669648, 17081983
S710 Phosphorylation HPRD 17081983
T711 Phosphorylation HPRD 17081983
S1018 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T193 A193 Biomuta DOID:4362 / cervical cancer [ tcga ]
S221 I221 Biomuta DOID:3571 / liver cancer [ icgc ]
S508 Y508 Biomuta DOID:363 / uterine cancer [ tcga ]
S515 C515 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S568 G568 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S573 T573 Biomuta DOID:1612 / breast cancer [ cosmic ]
S603 I603 Biomuta DOID:1324 / lung cancer [ tcga ]
S614 I614 Biomuta DOID:1324 / lung cancer [ tcga ]
K687 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T711 P711 Biomuta DOID:363 / uterine cancer [ tcga ]
K1024 N1024 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:11054 / urinary bladder cancer [ tcga ]