iPTMnet Report for Q8IX03 (WWC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IX03 / KIBRA_HUMAN
Protein Name Protein KIBRA
Gene Name Name: WWC1
Synonyms:KIAA0869;
Organism Homo sapiens (Human)

PRO ID PR:Q8IX03
DAG View
PRO Name protein KIBRA (human)
Definition A protein WWC1 that is encoded in the genome of human.
Short Label hWWC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IX03 (WWC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K117 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
S327 O-Glycosylation GlyGen 30379171
K347 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus   UniProt 23186163
S539 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 21878642, 22904328
S539 Phosphorylation O14965 (AURKA) PhosphoSitePlus   Signor 21878642
S539 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   Signor 21878642
S542 Phosphorylation PhosphoSitePlus   UniProt 22784093, 24269383
S542 Phosphorylation P06493 (CDK1) PhosphoSitePlus 22784093
S542 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 24269383
S542 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 24269383
S548 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 24269383
S548 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 24269383
S548 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 24269383
S623 Phosphorylation PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
Y781 Phosphorylation PhosphoSitePlus
Y786 Phosphorylation PhosphoSitePlus
Y788 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
T837 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus
T893 Phosphorylation PhosphoSitePlus
T895 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S899 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T901 Phosphorylation PhosphoSitePlus
T912 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S922 Phosphorylation PhosphoSitePlus
T923 Phosphorylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
T929 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 23186163, 24269383
T929 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus   Signor 24269383
T929 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   Signor 24269383
S931 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22784093, 18669648
S931 Phosphorylation P06493 (CDK1) PhosphoSitePlus 22784093
Y938 Phosphorylation PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
S947 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 15302935, 24269383, ...20068231
S947 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus   Signor 24269383
S947 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus   Signor 24269383
S962 Phosphorylation PhosphoSitePlus
S975 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 15081397
S975 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus 15081397
S978 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 15081397
S978 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus 15081397
T1006 Phosphorylation PhosphoSitePlus
S1081 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T895 Phosphorylation HPRD 18669648
S899 Phosphorylation HPRD 18669648
T912 Phosphorylation HPRD 18669648
S922 Phosphorylation HPRD 17924679
T923 Phosphorylation HPRD 17924679
S927 Phosphorylation HPRD 17924679
T929 Phosphorylation HPRD 18669648
S931 Phosphorylation HPRD 18669648
S947 Phosphorylation HPRD 18669648, 20068231
S975 Phosphorylation HPRD 15081397
S975 Phosphorylation Q05513 (PRKCZ) HPRD 15081397
S978 Phosphorylation HPRD 15081397
S978 Phosphorylation Q05513 (PRKCZ) HPRD 15081397
Site PTM Type PTM Enzyme Score Source PMID
S974 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y128 C128 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S141 F141 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K154 R154 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K161 E161 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S208 R208 Biomuta DOID:1324 / lung cancer [ cosmic ]
S255 Y255 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S327 R327 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S523 F523 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S525 F525 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T527 I527 Biomuta DOID:3571 / liver cancer [ cosmic ]
S533 F533 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S535 F535 Biomuta DOID:4159 / skin cancer [ cosmic ]
S539 P539 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S542 F542 Biomuta DOID:4159 / skin cancer [ cosmic ]
S542 T542 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S548 F548 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S899 P899 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S931 F931 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S962 F962 Biomuta DOID:4159 / skin cancer [ cosmic ]
S962 T962 Biomuta DOID:4159 / skin cancer [ cosmic ]
S975 L975 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1006 S1006 Biomuta DOID:10283 / prostate cancer [ cosmic ]