iPTMnet Report for Q8IWZ3 (ANKHD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWZ3 / ANKH1_HUMAN
Protein Name Ankyrin repeat and KH domain-containing protein 1
Gene Name Name: ANKHD1
Synonyms:KIAA1085,MASK,VBARP;ORFNames:PP2500;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWZ3
DAG View
PRO Name ankyrin repeat and KH domain-containing protein 1 (human)
Definition An ankyrin repeat and KH domain-containing protein 1 that is encoded in the genome of human.
Short Label hANKHD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWZ3 (ANKHD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S11 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 19690332
S105 Phosphorylation PhosphoSitePlus   UniProt 24275569
R136 Methylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
R173 Methylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
C181 S-Nitrosylation dbSNO 24105792
T191 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
C213 S-Nitrosylation dbSNO 26338901, 24105792
K223 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
C380 S-Nitrosylation dbSNO 24105792
K382 Ubiquitination PhosphoSitePlus
C535 S-Nitrosylation dbSNO 24105792
S557 Phosphorylation PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
S622 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
K666 Ubiquitination PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
Y772 Phosphorylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus   UniProt 23186163
K832 Acetylation PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
Y857 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
K1255 Ubiquitination PhosphoSitePlus
T1256 Phosphorylation PhosphoSitePlus
K1279 Ubiquitination PhosphoSitePlus
K1302 Ubiquitination PhosphoSitePlus
S1364 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
K1372 Ubiquitination PhosphoSitePlus
K1400 Ubiquitination PhosphoSitePlus
K1405 Ubiquitination PhosphoSitePlus
K1426 Ubiquitination PhosphoSitePlus
S1429 Phosphorylation PhosphoSitePlus
K1433 Ubiquitination PhosphoSitePlus
K1446 Ubiquitination PhosphoSitePlus
K1452 Acetylation PhosphoSitePlus
T1537 Phosphorylation PhosphoSitePlus
T1538 Phosphorylation PhosphoSitePlus
S1540 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1541 Phosphorylation PhosphoSitePlus
K1546 Acetylation PhosphoSitePlus
K1549 Acetylation PhosphoSitePlus
T1550 Phosphorylation PhosphoSitePlus
K1551 Acetylation PhosphoSitePlus
T1553 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1591 Phosphorylation PhosphoSitePlus
S1593 Phosphorylation PhosphoSitePlus
C1601 S-Nitrosylation dbSNO 26338901
S1611 Phosphorylation PhosphoSitePlus
Y1625 Phosphorylation PhosphoSitePlus
S1632 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1653 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1653 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1656 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1656 Phosphorylation PhosphoSitePlus
S1660 Phosphorylation PhosphoSitePlus
Y1661 Phosphorylation PhosphoSitePlus
K1662 Ubiquitination PhosphoSitePlus
T1663 Phosphorylation PhosphoSitePlus
S1665 Phosphorylation PhosphoSitePlus
S1669 Phosphorylation PhosphoSitePlus
S1670 Phosphorylation PhosphoSitePlus
T1678 Phosphorylation PhosphoSitePlus
S1679 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1681 Acetylation PhosphoSitePlus
K1685 Acetylation PhosphoSitePlus
K1691 Ubiquitination PhosphoSitePlus
S1705 Phosphorylation PhosphoSitePlus
R1713 Methylation PhosphoSitePlus
K1733 Ubiquitination PhosphoSitePlus
T1744 Phosphorylation PhosphoSitePlus
R1746 Methylation PhosphoSitePlus
K1776 Ubiquitination PhosphoSitePlus
T1781 Phosphorylation PhosphoSitePlus
S1784 Phosphorylation PhosphoSitePlus
K1786 Ubiquitination PhosphoSitePlus
S1787 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1787 Phosphorylation PhosphoSitePlus
S1793 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 32938750, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1794 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 32938750, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1798 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 32938750, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1799 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 32938750, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1802 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1803 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1813 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1816 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1817 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1820 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1821 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S1823 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T1824 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
K1830 Ubiquitination PhosphoSitePlus
K1833 Ubiquitination PhosphoSitePlus
T1837 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
R1840 Methylation PhosphoSitePlus
S1846 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
K1960 Ubiquitination PhosphoSitePlus
S2069 Phosphorylation PhosphoSitePlus
S2074 Phosphorylation PhosphoSitePlus
S2098 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
T2203 Phosphorylation IEDB 32387766
R2272 Methylation PhosphoSitePlus
S2275 Phosphorylation PhosphoSitePlus
S2279 O-Glycosylation GlyGen 32938750, 30620550
T2323 Phosphorylation PhosphoSitePlus
S2325 Phosphorylation PhosphoSitePlus
S2332 Phosphorylation PhosphoSitePlus
S2338 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S2357 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
S2398 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 35289036, 35254053, 22661428, 29237092, 34725712, 32119511, 30397120, 35132862, 28604694, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 21740066, 29351928, 34019948, 28510447
K2539 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T86 Phosphorylation HPRD 17081983
S93 Phosphorylation HPRD 17081983
S95 Phosphorylation HPRD 17081983, 18452278
S1593 Phosphorylation HPRD 19413330
S1670 Phosphorylation HPRD 19413330
S1679 Phosphorylation HPRD 19413330, 18767875
T1785 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
T86 Phosphorylation HPRD 17081983
S93 Phosphorylation HPRD 17081983
S95 Phosphorylation HPRD 17081983, 18452278
K601 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T86 Phosphorylation HPRD 17081983
S93 Phosphorylation HPRD 17081983
S95 Phosphorylation HPRD 17081983, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD   PhosphoSitePlus 20068231
S54 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S93 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S95 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231, 18452278
S101 Phosphorylation HPRD   PhosphoSitePlus 18452278
S105 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
K832 Acetylation PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
Y857 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
S887 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
K1255 Ubiquitination PhosphoSitePlus
T1256 Phosphorylation PhosphoSitePlus
K1279 Ubiquitination PhosphoSitePlus
K1302 Ubiquitination PhosphoSitePlus
K1372 Ubiquitination PhosphoSitePlus
K1400 Ubiquitination PhosphoSitePlus
K1405 Ubiquitination PhosphoSitePlus
K1426 Ubiquitination PhosphoSitePlus
S1429 Phosphorylation PhosphoSitePlus
K1433 Ubiquitination PhosphoSitePlus
K1446 Ubiquitination PhosphoSitePlus
K1452 Acetylation PhosphoSitePlus
T1537 Phosphorylation PhosphoSitePlus
T1538 Phosphorylation PhosphoSitePlus
S1540 Phosphorylation PhosphoSitePlus
T1541 Phosphorylation PhosphoSitePlus
K1546 Acetylation PhosphoSitePlus
K1549 Acetylation PhosphoSitePlus
T1550 Phosphorylation PhosphoSitePlus
K1551 Acetylation PhosphoSitePlus
T1553 Phosphorylation PhosphoSitePlus
S1591 Phosphorylation PhosphoSitePlus
S1593 Phosphorylation PhosphoSitePlus
S1611 Phosphorylation PhosphoSitePlus
Y1625 Phosphorylation PhosphoSitePlus
S1632 Phosphorylation PhosphoSitePlus
T1653 Phosphorylation PhosphoSitePlus
S1656 Phosphorylation PhosphoSitePlus
S1660 Phosphorylation PhosphoSitePlus
Y1661 Phosphorylation PhosphoSitePlus
K1662 Ubiquitination PhosphoSitePlus
S1665 Phosphorylation PhosphoSitePlus
S1669 Phosphorylation PhosphoSitePlus
S1670 Phosphorylation HPRD   PhosphoSitePlus 19664995
T1678 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1679 Phosphorylation HPRD   PhosphoSitePlus 18212344, 20068231
K1681 Acetylation PhosphoSitePlus
K1685 Acetylation PhosphoSitePlus
K1691 Ubiquitination PhosphoSitePlus
K1733 Ubiquitination PhosphoSitePlus
T1744 Phosphorylation PhosphoSitePlus
K1776 Ubiquitination PhosphoSitePlus
T1781 Phosphorylation PhosphoSitePlus
S1784 Phosphorylation PhosphoSitePlus
K1786 Ubiquitination PhosphoSitePlus
S1787 Phosphorylation PhosphoSitePlus
K1830 Ubiquitination PhosphoSitePlus
K1833 Ubiquitination PhosphoSitePlus
R1840 Methylation PhosphoSitePlus
K1960 Ubiquitination PhosphoSitePlus
S2069 Phosphorylation PhosphoSitePlus
S2074 Phosphorylation PhosphoSitePlus
S2275 Phosphorylation PhosphoSitePlus
S2279 Phosphorylation HPRD 20068231
T2280 Phosphorylation HPRD 18691976
S2281 Phosphorylation HPRD 18691976, 18669648
S2287 Phosphorylation HPRD 18669648
S2291 Phosphorylation HPRD 20068231
T2323 Phosphorylation HPRD   PhosphoSitePlus 18212344
S2325 Phosphorylation PhosphoSitePlus
S2332 Phosphorylation PhosphoSitePlus
T2344 Phosphorylation PhosphoSitePlus
S2539 Phosphorylation PhosphoSitePlus
S2556 Phosphorylation PhosphoSitePlus
T2582 Phosphorylation PhosphoSitePlus
S2595 Phosphorylation HPRD 20068231
S2598 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S64 G64 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S105 L105 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R136 C136 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R136 H136 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R173 Q173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S178 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C181 F181 Biomuta DOID:4159 / skin cancer [ cosmic ]
S198 N198 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K372 N372 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S557 F557 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K666 E666 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y772 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K848 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K855 E855 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1426 N1426 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1540 N1540 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1611 T1611 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y1625 N1625 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T1653 N1653 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1656 F1656 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1656 Y1656 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1713 K1713 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1746 S1746 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S1793 L1793 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1799 A1799 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T1813 I1813 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1821 M1821 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1823 P1823 Biomuta DOID:3571 / liver cancer [ cosmic ]
R1840 H1840 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1846 F1846 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]