iPTMnet Report for Q8IWY7


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWY7 / Q8IWY7_HUMAN
Protein Name Tau-tubulin kinase
Gene Name Name:
Organism Homo sapiens (Human)

Interactive Sequence View

Select/align proteoforms across species


Q8IWY7 as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S288 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
R294 Methylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K369 Acetylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K410 Acetylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K537 Acetylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
Y564 Phosphorylation PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
T658 Phosphorylation PhosphoSitePlus
K662 Sumoylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K345 E345 Biomuta DOID:3571 / liver cancer [ cosmic ]