iPTMnet Report for Q8IWW6 (ARHGAP12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWW6 / RHG12_HUMAN
Protein Name Rho GTPase-activating protein 12
Gene Name Name: ARHGAP12
Organism Homo sapiens (Human)

PRO ID PR:Q8IWW6
DAG View
PRO Name Rho GTPase-activating protein 12 (human)
Definition A Rho GTPase-activating protein 12 that is encoded in the genome of human.
Short Label hARHGAP12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWW6 (ARHGAP12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y63 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
S103 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T104 Phosphorylation phospho.ELM 18669648
S165 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
T174 Phosphorylation PhosphoSitePlus
S176 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S198 Phosphorylation PhosphoSitePlus
C199 S-Nitrosylation dbSNO 26338901
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S206 Phosphorylation PhosphoSitePlus
S213 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S215 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation phospho.ELM 18669648
T224 Phosphorylation PhosphoSitePlus
T230 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T231 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15144186, 24275569
S240 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186, 18669648, 19690332, ...24275569
Y243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 15144186
S262 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
Y355 Phosphorylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K366 Methylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K432 Methylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S592 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
K600 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
K614 Methylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
K796 Acetylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S91 Phosphorylation HPRD 20068231
S103 Phosphorylation HPRD 18669648
T104 Phosphorylation HPRD 18669648
S165 Phosphorylation HPRD 19651622, 20068231
S176 Phosphorylation HPRD 18669648
S201 Phosphorylation HPRD 19413330, 18669648
S213 Phosphorylation HPRD 18669648, 19415658
S215 Phosphorylation HPRD 18669648, 19415658, 18452278
S223 Phosphorylation HPRD 18669648
T230 Phosphorylation HPRD 19651622, 18669648, 17081983
T231 Phosphorylation HPRD 19413330, 19651622, 18669648, ...15144186, 20068231
S240 Phosphorylation HPRD 19413330, 19651622, 18669648, ...15144186, 20068231
Y243 Phosphorylation HPRD 15144186
S262 Phosphorylation HPRD 20068231
S395 Phosphorylation HPRD 20068231
S404 Phosphorylation HPRD 20068231
S592 Phosphorylation HPRD 18669648, 15345747
Site PTM Type PTM Enzyme Score Source PMID
S423 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S303 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S91 F91 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S198 P198 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S222 R222 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K614 N614 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y691 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S694 I694 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S694 C694 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K796 T796 Biomuta DOID:9256 / colorectal cancer [ cosmic ]