iPTMnet Report for Q8IWV8 (UBR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWV8 / UBR2_HUMAN
Protein Name E3 ubiquitin-protein ligase UBR2
Gene Name Name: UBR2
Synonyms:C6orf133,KIAA0349;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWV8
DAG View
PRO Name E3 ubiquitin-protein ligase UBR2 (human)
Definition An E3 ubiquitin-protein ligase UBR2 that is encoded in the genome of human.
Short Label hUBR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWV8 (UBR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
K27 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
C51 Methylation IEDB 31844290
K94 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
C686 Methylation IEDB 31844290
S734 Phosphorylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
T826 Phosphorylation PhosphoSitePlus
C837 Methylation IEDB 31844290
Y844 Phosphorylation PhosphoSitePlus
K994 Ubiquitination PhosphoSitePlus
S1005 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
T1008 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1009 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1014 Phosphorylation PhosphoSitePlus
T1017 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
K1044 Ubiquitination PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
K1142 Ubiquitination PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
K1255 Ubiquitination PhosphoSitePlus
T1266 Phosphorylation PhosphoSitePlus
K1273 Ubiquitination PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
T1312 Phosphorylation PhosphoSitePlus
K1599 Ubiquitination PhosphoSitePlus
Y1607 Phosphorylation PhosphoSitePlus
K1621 Ubiquitination PhosphoSitePlus
K1689 Ubiquitination PhosphoSitePlus
K1718 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T263 Phosphorylation HPRD 17081983
T1008 Phosphorylation HPRD 18669648
S1009 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 E2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K48 N48 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y274 C274 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K443 M443 Biomuta DOID:3571 / liver cancer [ cosmic ]
T581 A581 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K779 R779 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1312 I1312 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1607 H1607 Biomuta DOID:3571 / liver cancer [ cosmic ]