iPTMnet Report for Q8IWV1 (LAX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWV1 / LAX1_HUMAN
Protein Name Lymphocyte transmembrane adapter 1
Gene Name Name: LAX1
Synonyms:LAX;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWV1
DAG View
PRO Name lymphocyte transmembrane adapter 1 (human)
Definition A lymphocyte transmembrane adapter 1 that is encoded in the genome of human.
Short Label hLAX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWV1 (LAX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
R112 Methylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus   Signor   UniProt 12359715
Y193 Phosphorylation P06239 (LCK) Signor 12359715
Y193 Phosphorylation P43405 (SYK) Signor 12359715
Y268 Phosphorylation PhosphoSitePlus   Signor   UniProt 12359715
Y268 Phosphorylation P06239 (LCK) Signor 12359715
Y268 Phosphorylation P43405 (SYK) Signor 12359715
Y294 Phosphorylation PhosphoSitePlus   Signor   UniProt 12359715
Y294 Phosphorylation P06239 (LCK) Signor 12359715
Y294 Phosphorylation P43405 (SYK) Signor 12359715
K336 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y373 Phosphorylation PhosphoSitePlus   Signor   UniProt 19690332, 12359715
Y373 Phosphorylation P06239 (LCK) Signor 12359715
Y373 Phosphorylation P43405 (SYK) Signor 12359715


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R112 H112 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
R112 C112 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]