iPTMnet Report for Q8IWU9 (TPH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWU9 / TPH2_HUMAN
Protein Name Tryptophan 5-hydroxylase 2
Gene Name Name: TPH2
Synonyms:NTPH;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWU9
DAG View
PRO Name tryptophan 5-hydroxylase 2 (human)
Definition A tryptophan 5-hydroxylase 2 that is encoded in the genome of human.
Short Label hTPH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWU9 (TPH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 15663479, 17973628, 17727633, ...18339632
S19 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 15663479, 17973628, 18339632
K79 Acetylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus   RLIMS-P 17973628
Y249 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
S382 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S392 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
Site PTM Type PTM Enzyme Score Source PMID
S382 Phosphorylation HPRD 17287340
S392 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y252 H252 Biomuta DOID:1324 / lung cancer [ cosmic ]
S392 C392 Biomuta DOID:1612 / breast cancer [ icgc ]