Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWU2 / LMTK2_HUMAN
Protein Name Serine/threonine-protein kinase LMTK2
Gene Name Name: LMTK2
Synonyms:AATYK2,BREK,KIAA1079,KPI2,LMR2;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWU2
DAG View
PRO Name serine/threonine-protein kinase LMTK2 (human)
Definition A serine/threonine-protein kinase LMTK2 that is encoded in the genome of human.
Short Label hLMTK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWU2 (LMTK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T90 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
Y500 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
T876 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus   UniProt 23186163
S901 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
T996 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
T1088 Phosphorylation PhosphoSitePlus
Y1100 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1111 Phosphorylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
T1123 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
S1248 Phosphorylation PhosphoSitePlus
S1251 Phosphorylation PhosphoSitePlus
S1291 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus
S1305 Phosphorylation HPRD 17081983
S1307 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1308 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1310 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1397 Phosphorylation PhosphoSitePlus
T1445 Phosphorylation PhosphoSitePlus
S1446 Phosphorylation PhosphoSitePlus
Y1448 Phosphorylation PhosphoSitePlus
S1450 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   Signor   UniProt 22220831, 12832520, 23186163
S1465 Phosphorylation PhosphoSitePlus
Y1468 Phosphorylation PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus
S1497 Phosphorylation PhosphoSitePlus


Q8IWU2 (LMTK2) as PTM Enzyme



Substrate Site Score Source PMID
P11216 (PYGB) S15 PhosphoSitePlus 16887929
P13569 (CFTR) S737 neXtProt   PhosphoSitePlus 16887929, 24727471
P62136 (PPP1CA) T320 neXtProt   PhosphoSitePlus   Signor 22220831, 21996745, 12393858


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T582 S582 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S671 F671 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S955 F955 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T996 S996 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1117 F1117 Biomuta DOID:363 / uterine cancer [ tcga ]
S1251 F1251 Biomuta DOID:1909 / melanoma [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S1305 I1305 Biomuta DOID:363 / uterine cancer [ tcga ]
T1445 S1445 Biomuta DOID:1909 / melanoma [ cosmic ]
S1489 L1489 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]