iPTMnet Report for Q8IWU2 (LMTK2)
Protein Information
| UniProt AC / UniProt ID | Q8IWU2 / LMTK2_HUMAN |
| Protein Name | Serine/threonine-protein kinase LMTK2 |
| Gene Name | Name: LMTK2 Synonyms:AATYK2,BREK,KIAA1079,KPI2,LMR2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8IWU2 |
| PRO Name | serine/threonine-protein kinase LMTK2 (human) |
| Definition | A serine/threonine-protein kinase LMTK2 that is encoded in the genome of human. |
| Short Label | hLMTK2 |
| Category | organism-gene |
DAG ViewQ8IWU2 (LMTK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T90 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K150 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K177 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K292 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S418 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K430 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y476 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S490 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y500 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S525 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T582 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S587 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S594 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T602 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S630 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S671 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S679 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S788 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T876 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S883 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S886 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S901 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S955 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T996 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1012 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1088 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1100 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1107 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S1111 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1117 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1123 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1124 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1126 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1248 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1291 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1305 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S1307 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17081983 | ||
| S1308 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17081983 | ||
| S1310 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17081983 | ||
| S1397 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1445 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1446 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1448 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1450 | Phosphorylation | Q00535 (CDK5) | score4 | neXtProt PhosphoSitePlus Signor UniProt | 22220831, 12832520, 23186163 | |
| S1465 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1468 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1489 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1496 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1497 | Phosphorylation | score1 | PhosphoSitePlus |
Q8IWU2 (LMTK2) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P11216 (PYGB) | S15 | score2 | PhosphoSitePlus | 16887929 | |
| P13569 (CFTR) | S737 | score4 | neXtProt PhosphoSitePlus | 16887929, 24727471 | |
| P62136 (PPP1CA) | T320 | score4 | neXtProt PhosphoSitePlus Signor | 22220831, 21996745, 12393858 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K292 | N292 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T582 | S582 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| S671 | F671 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S955 | F955 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S955 | Y955 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T996 | S996 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S1117 | F1117 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] | |
| S1126 | F1126 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1251 | F1251 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S1305 | N1305 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T1445 | S1445 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S1489 | L1489 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |
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