Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWT6 / LRC8A_HUMAN
Protein Name Volume-regulated anion channel subunit LRRC8A
Gene Name Name: LRRC8A
Synonyms:KIAA1437,LRRC8,SWELL1;ORFNames:UNQ221/PRO247;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWT6
DAG View
PRO Name volume-regulated anion channel subunit LRRC8A (human)
Definition A volume-regulated anion channel subunit LRRC8A that is encoded in the genome of human.
Short Label hLRRC8A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWT6 (LRRC8A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S64 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
T133 Phosphorylation HPRD   PhosphoSitePlus 18452278
T149 Phosphorylation HPRD   PhosphoSitePlus 18452278
S150 Phosphorylation HPRD   PhosphoSitePlus 18452278
K184 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S199 Phosphorylation HPRD   PhosphoSitePlus 18452278
S202 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus   UniProt 23186163
S217 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18578522, 19651622
S227 Phosphorylation HPRD   PhosphoSitePlus 17081983
T229 Phosphorylation HPRD 17081983
K241 Ubiquitination PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
Y386 Phosphorylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
K799 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T133 M133 Biomuta DOID:3070 / malignant glioma [ cosmic, tcga ]
S150 N150 Biomuta DOID:1324 / lung cancer [ cosmic ]
S198 * Biomuta DOID:9256 / colorectal cancer [ icgc ]
S202 G202 Biomuta DOID:3571 / liver cancer [ tcga ]
S217 * Biomuta DOID:1324 / lung cancer [ tcga ]
T229 M229 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T628 A628 Biomuta DOID:1793 / pancreatic cancer [ icgc ]