iPTMnet Report for Q8IWJ2 (GCC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWJ2 / GCC2_HUMAN
Protein Name GRIP and coiled-coil domain-containing protein 2
Gene Name Name: GCC2
Synonyms:KIAA0336,RANBP2L4;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWJ2
DAG View
PRO Name GRIP and coiled-coil domain-containing protein 2 (human)
Definition A GRIP and coiled-coil domain-containing protein 2 that is encoded in the genome of human.
Short Label hGCC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWJ2 (GCC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
S11 Phosphorylation PhosphoSitePlus   UniProt 20068231
T14 Phosphorylation PhosphoSitePlus   UniProt 20068231
K32 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus   UniProt 21406692
K245 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K403 Acetylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
T492 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
T560 Phosphorylation IEDB 35494241
S591 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
C798 Methylation IEDB 31844290
K813 Ubiquitination PhosphoSitePlus
K816 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
K840 Ubiquitination PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
K952 Acetylation PhosphoSitePlus
K958 Acetylation PhosphoSitePlus
T988 Phosphorylation PhosphoSitePlus
R1010 Methylation PhosphoSitePlus
T1141 Phosphorylation PhosphoSitePlus
K1410 Acetylation PhosphoSitePlus
S1483 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
S1487 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1490 Phosphorylation PhosphoSitePlus
K1492 Ubiquitination PhosphoSitePlus
T1500 Phosphorylation PhosphoSitePlus
T1509 Phosphorylation PhosphoSitePlus
S1542 Phosphorylation PhosphoSitePlus
K1558 Ubiquitination PhosphoSitePlus
K1564 Ubiquitination PhosphoSitePlus
S1566 Phosphorylation PhosphoSitePlus
K1570 Ubiquitination PhosphoSitePlus
S1571 Phosphorylation PhosphoSitePlus
K1594 Ubiquitination PhosphoSitePlus
K1597 Ubiquitination PhosphoSitePlus
K1611 Ubiquitination PhosphoSitePlus
S1612 Phosphorylation PhosphoSitePlus
Y1618 Phosphorylation PhosphoSitePlus
K1630 Ubiquitination PhosphoSitePlus
S1649 Phosphorylation PhosphoSitePlus
S1668 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 20068231
T14 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD 20068231
S287 Phosphorylation HPRD 18691976
S937 Phosphorylation HPRD 18491316
S945 Phosphorylation HPRD 20068231
T988 Phosphorylation HPRD 18491316
S1483 Phosphorylation HPRD 18669648, 16964243, 20068231
S1542 Phosphorylation HPRD 18669648
S1649 Phosphorylation HPRD 18691976, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S446 T446 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K500 E500 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S507 L507 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S591 Y591 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S606 F606 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
C798 Y798 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S935 L935 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1487 F1487 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1558 N1558 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1566 R1566 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1570 N1570 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1597 E1597 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1597 R1597 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
K1611 T1611 Biomuta DOID:363 / uterine cancer [ icgc ]
S1612 Y1612 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1612 C1612 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]