iPTMnet Report for Q8IWI9 (MGA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWI9 / MGAP_HUMAN
Protein Name MAX gene-associated protein
Gene Name Name: MGA
Synonyms:KIAA0518,MAD5;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWI9
DAG View
PRO Name MAX gene-associated protein (human)
Definition A MAX gene-associated protein that is encoded in the genome of human.
Short Label hMGA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWI9 (MGA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation IEDB   PhosphoSitePlus 27869121
T98 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K349 Sumoylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
K382 Sumoylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K460 Sumoylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y543 Phosphorylation IEDB 35494241
K547 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
K570 Sumoylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus   UniProt 23186163
K613 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
S645 Phosphorylation IEDB   PhosphoSitePlus   UniProt 32387766, 19690332
S648 Phosphorylation PhosphoSitePlus
T649 Phosphorylation PhosphoSitePlus
K654 Sumoylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K798 Acetylation PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus   UniProt 23186163
S861 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S876 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
Y915 Phosphorylation PhosphoSitePlus
Y921 Phosphorylation PhosphoSitePlus
S924 Phosphorylation IEDB   PhosphoSitePlus   UniProt 23186163, 18669648, 32387766
K928 Methylation PhosphoSitePlus
K928 Sumoylation PhosphoSitePlus
K937 Methylation PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
K990 Ubiquitination PhosphoSitePlus
T1113 Phosphorylation PhosphoSitePlus
K1140 Ubiquitination PhosphoSitePlus
K1162 Sumoylation PhosphoSitePlus
S1195 Phosphorylation PhosphoSitePlus
K1201 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T1213 Phosphorylation PhosphoSitePlus
K1291 Ubiquitination PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
K1307 Ubiquitination PhosphoSitePlus
K1310 Ubiquitination PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus
K1334 Ubiquitination PhosphoSitePlus
S1371 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S1371 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
K1386 Ubiquitination PhosphoSitePlus
S1412 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
T1416 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
S1430 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1439 Phosphorylation PhosphoSitePlus
K1448 Ubiquitination PhosphoSitePlus
S1457 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K1461 Ubiquitination PhosphoSitePlus
S1470 Phosphorylation PhosphoSitePlus
S1481 Phosphorylation PhosphoSitePlus
S1488 Phosphorylation PhosphoSitePlus
T1493 Phosphorylation PhosphoSitePlus
S1499 Phosphorylation PhosphoSitePlus
K1502 Ubiquitination PhosphoSitePlus
S1506 O-Glycosylation GlyGen 30379171
S1506 Phosphorylation PhosphoSitePlus
K1516 Ubiquitination PhosphoSitePlus
K1519 Acetylation PhosphoSitePlus
K1525 Acetylation PhosphoSitePlus
S1533 Phosphorylation PhosphoSitePlus
K1552 Ubiquitination PhosphoSitePlus
S1557 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 34846842, 30379171, ...32574038, 32938750, 30059200, 21740066, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T1558 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T1558 Phosphorylation PhosphoSitePlus
T1561 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 32938750, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T1565 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S1569 Phosphorylation PhosphoSitePlus
S1573 Phosphorylation PhosphoSitePlus
T1579 Phosphorylation PhosphoSitePlus
S1630 Phosphorylation IEDB 32387766
T1633 Phosphorylation PhosphoSitePlus
T1663 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T1664 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T1667 O-Glycosylation GlyGen 34846842, 32574038
T1668 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T1668 Phosphorylation PhosphoSitePlus
S1672 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 32938750, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
R1761 Methylation PhosphoSitePlus
R1818 Methylation PhosphoSitePlus
S1820 Phosphorylation PhosphoSitePlus
T1822 Phosphorylation PhosphoSitePlus
S1875 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S1905 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S1905 Phosphorylation PhosphoSitePlus
S1911 O-Glycosylation GlyGen 23301498, 34846842, 30379171, ...32574038, 30059200, 35254053, 35132862, 30620550, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S1914 Phosphorylation PhosphoSitePlus
K1915 Ubiquitination PhosphoSitePlus
T1916 Phosphorylation PhosphoSitePlus
K1985 Sumoylation PhosphoSitePlus
K1992 Ubiquitination PhosphoSitePlus
S1996 Phosphorylation PhosphoSitePlus
S2024 Phosphorylation PhosphoSitePlus
K2113 Sumoylation PhosphoSitePlus
S2127 Phosphorylation PhosphoSitePlus
K2135 Sumoylation PhosphoSitePlus
S2143 Phosphorylation PhosphoSitePlus
S2166 Phosphorylation PhosphoSitePlus
T2183 Phosphorylation PhosphoSitePlus
K2238 Sumoylation PhosphoSitePlus
S2243 Phosphorylation PhosphoSitePlus
S2248 Phosphorylation PhosphoSitePlus
R2265 Methylation PhosphoSitePlus   UniProt 24129315
K2284 Sumoylation PhosphoSitePlus
S2376 Phosphorylation PhosphoSitePlus
K2378 Ubiquitination PhosphoSitePlus
K2404 Ubiquitination PhosphoSitePlus
K2406 Acetylation PhosphoSitePlus
K2406 Sumoylation PhosphoSitePlus
K2406 Ubiquitination PhosphoSitePlus
K2413 Ubiquitination PhosphoSitePlus
Y2423 Phosphorylation PhosphoSitePlus
Y2424 Phosphorylation PhosphoSitePlus
K2445 Ubiquitination PhosphoSitePlus
T2449 Phosphorylation PhosphoSitePlus
K2460 Ubiquitination PhosphoSitePlus
K2480 Ubiquitination PhosphoSitePlus
K2485 Ubiquitination PhosphoSitePlus
S2500 Phosphorylation PhosphoSitePlus
K2513 Ubiquitination PhosphoSitePlus
K2520 Ubiquitination PhosphoSitePlus
S2535 Phosphorylation PhosphoSitePlus
S2541 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S2574 Phosphorylation PhosphoSitePlus
S2585 Phosphorylation PhosphoSitePlus
T2599 Phosphorylation PhosphoSitePlus
S2620 Phosphorylation PhosphoSitePlus
T2655 Phosphorylation PhosphoSitePlus
K2698 Acetylation PhosphoSitePlus
K2698 Ubiquitination PhosphoSitePlus
T2712 Phosphorylation IEDB 35494241
Y2727 Phosphorylation PhosphoSitePlus
S2734 Phosphorylation PhosphoSitePlus
K2738 Ubiquitination PhosphoSitePlus
K2745 Ubiquitination PhosphoSitePlus
K2746 Ubiquitination PhosphoSitePlus
K2777 Acetylation PhosphoSitePlus
K2777 Ubiquitination PhosphoSitePlus
S2787 Phosphorylation PhosphoSitePlus
K2866 Ubiquitination PhosphoSitePlus
K2885 Ubiquitination PhosphoSitePlus
S2898 Phosphorylation PhosphoSitePlus
S2910 Phosphorylation PhosphoSitePlus   UniProt 19690332
S2921 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S2962 Phosphorylation PhosphoSitePlus
S2963 Phosphorylation PhosphoSitePlus
T2966 Phosphorylation PhosphoSitePlus
S2978 Phosphorylation PhosphoSitePlus   UniProt 23186163
S3007 Phosphorylation PhosphoSitePlus
S3059 Phosphorylation PhosphoSitePlus
K3065 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T407 Phosphorylation HPRD 18452278
Y414 Phosphorylation HPRD 18452278
S415 Phosphorylation HPRD 18452278
S417 Phosphorylation HPRD 18452278
S448 Phosphorylation HPRD 19413330
S449 Phosphorylation HPRD 19413330, 18669648
S451 Phosphorylation HPRD 20068231
S534 Phosphorylation HPRD 20068231
S607 Phosphorylation HPRD 19413330, 19664995
S917 Phosphorylation HPRD 20068231
S924 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20058876, 20068231
S1195 Phosphorylation HPRD 20068231
T1204 Phosphorylation HPRD 20068231
S1208 Phosphorylation HPRD 18669648, 20068231
S1412 Phosphorylation HPRD 18452278
T1416 Phosphorylation HPRD 18452278
S1422 Phosphorylation HPRD 18452278
S1430 Phosphorylation HPRD 19651622, 20068231
S1457 Phosphorylation HPRD 18669648, 20068231
S1542 Phosphorylation PhosphoSitePlus
R1552 Methylation PhosphoSitePlus
S1562 Phosphorylation PhosphoSitePlus
R1566 Methylation PhosphoSitePlus
R1577 Methylation PhosphoSitePlus
S1815 Phosphorylation HPRD 19651622, 18452278
S2291 Phosphorylation HPRD 18452278
S2332 Phosphorylation HPRD 20068231, 18452278
S2689 Phosphorylation HPRD 18669648, 18452278
S2701 Phosphorylation HPRD 18452278
S2712 Phosphorylation HPRD 19413330, 19651622
S2850 Phosphorylation HPRD 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y200 S200 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S359 N359 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S360 I360 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S369 P369 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic ]
T407 I407 Biomuta DOID:1324 / lung cancer [ cosmic ]
S448 G448 Biomuta DOID:363 / uterine cancer [ cosmic ]
S572 L572 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S607 F607 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K613 R613 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K624 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K634 N634 Biomuta DOID:363 / uterine cancer [ cosmic ]
S645 R645 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S704 P704 Biomuta DOID:363 / uterine cancer [ icgc ]
K708 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S736 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S736 L736 Biomuta DOID:1324 / lung cancer [ cosmic ]
S879 F879 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y915 * Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ]
S917 F917 Biomuta DOID:1324 / lung cancer [ cosmic ]
S924 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S924 L924 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K937 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1201 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K1307 R1307 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1307 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K1334 Q1334 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1378 Y1378 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
T1416 I1416 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1422 F1422 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1430 Y1430 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1481 F1481 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1481 T1481 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S1488 F1488 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1499 F1499 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1506 Y1506 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1533 C1533 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1542 P1542 Biomuta DOID:184 / bone cancer [ cosmic ]
R1552 Q1552 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1552 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
T1561 I1561 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1562 Y1562 Biomuta DOID:363 / uterine cancer [ cosmic ]
R1566 I1566 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1577 W1577 Biomuta DOID:363 / uterine cancer [ cosmic ]
T1663 I1663 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1664 I1664 Biomuta [ cosmic ]
T1668 I1668 Biomuta DOID:363 / uterine cancer [ icgc ]
R1761 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
R1761 Q1761 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1818 Q1818 Biomuta DOID:1319 / brain cancer [ icgc ]
R1818 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1820 C1820 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1905 F1905 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1911 N1911 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1985 T1985 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1992 N1992 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1992 T1992 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2127 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S2143 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S2376 P2376 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y2424 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
K2460 E2460 Biomuta DOID:363 / uterine cancer [ icgc ]
S2620 C2620 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S2620 F2620 Biomuta DOID:1612 / breast cancer [ cosmic ]
S2701 F2701 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2712 M2712 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y2727 D2727 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K2745 I2745 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K2746 T2746 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K2746 R2746 Biomuta DOID:3571 / liver cancer [ cosmic ]
K2777 I2777 Biomuta DOID:263 / kidney cancer [ cosmic ]
K2777 R2777 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2910 F2910 Biomuta DOID:4159 / skin cancer [ cosmic ]