iPTMnet Report for Q8IWF6 (DENND6A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWF6 / DEN6A_HUMAN
Protein Name Protein DENND6A
Gene Name Name: DENND6A
Synonyms:FAM116A;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWF6
DAG View
PRO Name protein DENND6A (human)
Definition A protein FAM116A that is encoded in the genome of human.
Short Label hDENND6A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWF6 (DENND6A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S127 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K199 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K510 Methylation PhosphoSitePlus   UniProt 24129315
K564 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S127 L127 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K199 N199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K375 N375 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K421 N421 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K469 N469 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]