iPTMnet Report for Q8IWE5 (PLEKHM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWE5 / PKHM2_HUMAN
Protein Name Pleckstrin homology domain-containing family M member 2
Gene Name Name: PLEKHM2
Synonyms:KIAA0842,SKIP;
Organism Homo sapiens (Human)

PRO ID PR:Q8IWE5
DAG View
PRO Name pleckstrin homology domain-containing family M member 2 (human)
Definition A pleckstrin homology domain-containing family M member 2 that is encoded in the genome of human.
Short Label hPLEKHM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWE5 (PLEKHM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K7 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
Y647 Phosphorylation PhosphoSitePlus
Y655 Phosphorylation PhosphoSitePlus
Y660 Phosphorylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
C850 Methylation IEDB 31844290
K917 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T439 Phosphorylation HPRD 18491316
S441 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S334 G334 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T439 A439 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S441 F441 Biomuta DOID:4159 / skin cancer [ cosmic ]