iPTMnet Report for Q8IWA4 (MFN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IWA4 / MFN1_HUMAN
Protein Name Mitofusin-1
Gene Name Name: MFN1
Organism Homo sapiens (Human)

PRO ID PR:Q8IWA4
DAG View
PRO Name mitofusin-1 (human)
Definition A mitofusin-1 that is encoded in the genome of human.
Short Label hMFN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IWA4 (MFN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S6 Phosphorylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
R47 Methylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
C498 Methylation IEDB 31844290
K499 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
T562 Phosphorylation RLIMS-P 25801171
T564 Phosphorylation RLIMS-P 25801171
K643 Ubiquitination PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
T687 Phosphorylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048376 (hMFN1/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 C6 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K9 N9 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R47 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R47 Q47 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K77 Q77 Biomuta DOID:363 / uterine cancer [ icgc ]
K122 N122 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K166 N166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C498 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K499 N499 Biomuta DOID:363 / uterine cancer [ icgc ]