iPTMnet Report for Q8IW41 (MAPKAPK5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IW41 / MAPK5_HUMAN
Protein Name MAP kinase-activated protein kinase 5
Gene Name Name: MAPKAPK5
Synonyms:PRAK;
Organism Homo sapiens (Human)

PRO ID PR:Q8IW41
DAG View
PRO Name MAP kinase-activated protein kinase 5 (human)
Definition A MAP kinase-activated protein kinase 5 that is encoded in the genome of human.
Short Label hMAPKAPK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IW41 (MAPKAPK5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S93 Phosphorylation RLIMS-P 20647589
S115 Phosphorylation P17612 (PRKACA) neXtProt   PRO   PhosphoSitePlus   RLIMS-P 17947239, 20734105
K123 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T182 Phosphorylation P53778 (MAPK12) , P28482 (MAPK1) , O15264 (MAPK13) , P45984 (MAPK9) , Q15759 (MAPK11) , Q16539 (MAPK14) , Q16659 (MAPK6) , P31152 (MAPK4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 15577943, 24651460, ...19473979, 18669648, 9628874, 21666810, 28252035, 19690332
T186 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus   UniProt 12808055
T214 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation RLIMS-P 24651460
K286 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus   UniProt 23186163
T368 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T182 Phosphorylation Q15759 (MAPK11) , Q16539 (MAPK14) HPRD 18669648, 9628874
T214 Phosphorylation HPRD 19413330
S472 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
T182 Phosphorylation Q15759 (MAPK11) , Q16539 (MAPK14) HPRD 18669648, 9628874
T214 Phosphorylation HPRD 19413330
S470 Phosphorylation HPRD 19413330


Q8IW41 (MAPKAPK5) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S377 HPRD   neXtProt 12171600
O43524 (FOXO3) S215 neXtProt 21329882
O60229 (KALRN) S487 neXtProt   PhosphoSitePlus 22508986
P04637-1 (TP53) S37 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17254968
P04792 (HSPB1) S15 neXtProt 9628874, 21575178, 19166925
P04792 (HSPB1) S78 neXtProt 9628874, 21575178, 19166925
P04792 (HSPB1) S82 neXtProt 9628874, 21575178, 19166925
P07101-3 (TH) S19 PhosphoSitePlus   Signor 12421349, 19801645
P07101-3 (TH) S40 PhosphoSitePlus 12421349
P07101-3 (TH) S404 PhosphoSitePlus 12421349
P25685 (DNAJB1) S149 PhosphoSitePlus   Signor 24309468
P25685 (DNAJB1) S151 PhosphoSitePlus   Signor 24309468
P25685 (DNAJB1) S171 PhosphoSitePlus   Signor 24309468
P31152 (MAPK4) S186 Signor 1319925
P47712 (PLA2G4A) S727 HPRD   Signor 16964243, 19664994, 18669648, ...10978317, 20068231, 18212344
Q15382 (RHEB) S130 neXtProt   PhosphoSitePlus 21336308
Q92599 (SEPTIN8) S163 PhosphoSitePlus 22649572
Q92599 (SEPTIN8) S192 PhosphoSitePlus 22649572


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048332 (hMAPKAPK5/Phos:1) pS115 PRO
PR:000048333 (hMAPKAPK5/Phos:2) pT182 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S115 I115 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T182 P182 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T186 I186 Biomuta [ cosmic ]
S212 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T214 M214 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K286 N286 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S470 Y470 Biomuta DOID:4159 / skin cancer [ cosmic ]
S472 Y472 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]