iPTMnet Report for Q8IVU3 (HERC6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVU3 / HERC6_HUMAN
Protein Name Probable E3 ubiquitin-protein ligase HERC6
Gene Name Name: HERC6
Organism Homo sapiens (Human)

PRO ID PR:Q8IVU3
DAG View
PRO Name probable E3 ubiquitin-protein ligase HERC6 (human)
Definition A probable E3 ubiquitin-protein ligase HERC6 that is encoded in the genome of human.
Short Label hHERC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVU3 (HERC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K389 Methylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
C557 Methylation IEDB 31844290
K560 Ubiquitination PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
Y859 Phosphorylation PhosphoSitePlus
Y862 Phosphorylation IEDB 35494241
S867 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T458 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K154 N154 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K164 N164 Biomuta DOID:1324 / lung cancer [ cosmic ]
S168 F168 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S271 I271 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S385 T385 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K806 E806 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y862 F862 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y862 C862 Biomuta DOID:5041 / esophageal cancer [ cosmic ]