iPTMnet Report for Q8IVT5 (KSR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVT5 / KSR1_HUMAN
Protein Name Kinase suppressor of Ras 1
Gene Name Name: KSR1
Synonyms:KSR;
Organism Homo sapiens (Human)

PRO ID PR:Q8IVT5
DAG View
PRO Name kinase suppressor of Ras 1 (human)
Definition A kinase suppressor of Ras 1 that is encoded in the genome of human.
Short Label hKSR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVT5 (KSR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K61 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus   UniProt 18088087, 18669648, 23186163, ...18220336
T273 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T288 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S309 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087, 17081983
S311 Phosphorylation PRO   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983
S314 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S351 Phosphorylation PhosphoSitePlus   UniProt 23186163
T404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation O43318 (MAP3K7) , P15531 (NME1) PRO   PhosphoSitePlus   Signor   UniProt 23186163, 18669648, 11741534, ...12941695, 12105213, 19690332
S409 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus   UniProt 23186163
T473 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S597 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
Y602 Phosphorylation PRO
K656 Acetylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
K709 Acetylation PhosphoSitePlus
Y723 Phosphorylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
S888 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 21102438
K903 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T133 Phosphorylation HPRD 18669648, 18088087
T137 Phosphorylation P28482 (MAPK1) HPRD 18669648, 9858547
T151 Phosphorylation P28482 (MAPK1) HPRD 9858547
S174 Phosphorylation HPRD 19651622, 18088087, 9858547
S197 Phosphorylation HPRD 18669648
S269 Phosphorylation HPRD 18669648, 19664994, 9858547, ...20230923
S320 Phosphorylation P28482 (MAPK1) HPRD 9858547
S432 Phosphorylation HPRD 18669648


Q8IVT5 (KSR1) as PTM Enzyme



Substrate Site Score Source PMID
P04049 (RAF1) T269 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7477354, 11134016, 9094715, ...19766101


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048142 (hKSR1/Phos:1) pS311 PRO
PR:000048143 (hKSR1/Phos:2) pS311,pY602 PRO
PR:000048144 (hKSR1/Phos:3) pS311,pS406 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P15056 (BRAF) S729 Q8IVT5 (KSR1) inhibited_association eFIP 24095280


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T137 P137 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T151 M151 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S269 Y269 Biomuta DOID:1324 / lung cancer [ cosmic ]