iPTMnet Report for Q8IVL5 (P3H2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVL5 / P3H2_HUMAN
Protein Name Prolyl 3-hydroxylase 2 precursor
Gene Name Name: P3H2
Synonyms:LEPREL1;
Organism Homo sapiens (Human)

PRO ID PR:Q8IVL5
DAG View
PRO Name prolyl 3-hydroxylase 2 (human)
Definition A prolyl 3-hydroxylase 2 that is encoded in the genome of human.
Short Label hP3H2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVL5 (P3H2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S112 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
C247 Methylation IEDB 31844290
C251 Methylation IEDB 31844290
C328 Methylation IEDB 31844290
K373 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
C476 Methylation IEDB 31844290
K496 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
C561 Methylation IEDB 31844290
C584 Methylation IEDB 31844290
C593 Methylation IEDB 31844290
K635 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
C638 Methylation IEDB 31844290
K655 Ubiquitination PhosphoSitePlus
K705 Methylation PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S112 F112 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C247 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K496 N496 Biomuta DOID:263 / kidney cancer [ cosmic ]
C561 R561 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C561 S561 Biomuta DOID:4159 / skin cancer [ cosmic ]