iPTMnet Report for Q8IVL1 (NAV2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVL1 / NAV2_HUMAN
Protein Name Neuron navigator 2
Gene Name Name: NAV2
Synonyms:HELAD1,KIAA1419,POMFIL2,RAINB1,STEERIN2;
Organism Homo sapiens (Human)

PRO ID PR:Q8IVL1
DAG View
PRO Name neuron navigator 2 (human)
Definition A neuron navigator 2 that is encoded in the genome of human.
Short Label hNAV2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVL1 (NAV2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N137 N-Glycosylation GlyGen 29391424
S309 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
K422 Acetylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S481 Phosphorylation IEDB   PhosphoSitePlus 34171305
R496 Methylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
N784 N-Glycosylation GlyGen 29391424
S856 Phosphorylation PhosphoSitePlus
Y906 Phosphorylation PhosphoSitePlus
Y915 Phosphorylation PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
K1024 Acetylation PhosphoSitePlus
K1030 Acetylation PhosphoSitePlus
S1036 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation PhosphoSitePlus
T1075 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1113 Phosphorylation PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
S1120 Phosphorylation PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus
T1135 Phosphorylation PhosphoSitePlus
K1146 Methylation PhosphoSitePlus
K1147 Methylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
T1159 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
T1166 Phosphorylation PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1202 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1215 Phosphorylation PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
S1236 Phosphorylation PhosphoSitePlus
N1240 N-Glycosylation GlyGen 29671580, 29391424
S1245 Phosphorylation PhosphoSitePlus
S1263 Phosphorylation PhosphoSitePlus
S1264 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
S1280 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
N1282 N-Glycosylation GlyGen 29391424
S1284 Phosphorylation PhosphoSitePlus
S1287 Phosphorylation PhosphoSitePlus
S1301 Phosphorylation phospho.ELM 18669648
S1302 Phosphorylation PhosphoSitePlus
Y1314 Phosphorylation PhosphoSitePlus
S1319 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 18669648, 31848261
T1321 Phosphorylation PhosphoSitePlus
S1365 Phosphorylation phospho.ELM 18669648
S1372 Phosphorylation phospho.ELM 18669648
S1375 Phosphorylation PhosphoSitePlus
S1376 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1388 Phosphorylation PhosphoSitePlus
S1480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S1484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1488 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S1494 Phosphorylation PhosphoSitePlus
T1495 Phosphorylation PhosphoSitePlus
S1502 Phosphorylation PhosphoSitePlus
T1510 Phosphorylation PhosphoSitePlus
T1519 Phosphorylation PhosphoSitePlus
K1531 Ubiquitination PhosphoSitePlus
S1536 Phosphorylation PhosphoSitePlus
S1538 Phosphorylation PhosphoSitePlus
T1545 O-Glycosylation GlyGen 30379171, 32574038, 30059200, ...35254053, 31492838, 30620550, 29237092
T1545 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1549 O-Glycosylation GlyGen 30379171, 32574038, 30059200, ...35254053, 31492838, 30620550, 29237092
S1549 Phosphorylation PhosphoSitePlus
S1552 O-Glycosylation GlyGen 30379171, 32574038, 30059200, ...35254053, 31492838, 30620550, 29237092
T1558 Phosphorylation PhosphoSitePlus
S1559 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1582 Phosphorylation PhosphoSitePlus
T1589 Phosphorylation phospho.ELM 18669648
S1591 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1593 Phosphorylation PhosphoSitePlus
Y1602 Phosphorylation PhosphoSitePlus
T1603 Phosphorylation PhosphoSitePlus
S1610 Phosphorylation PhosphoSitePlus
S1611 Phosphorylation PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
S1703 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T1732 Phosphorylation PhosphoSitePlus
S1737 Phosphorylation PhosphoSitePlus
T1776 Phosphorylation PhosphoSitePlus
N1784 N-Glycosylation GlyGen 29391424
S1799 Phosphorylation PhosphoSitePlus
S1800 Phosphorylation PhosphoSitePlus
K1825 Acetylation PhosphoSitePlus
K1826 Acetylation PhosphoSitePlus
S1854 Phosphorylation phospho.ELM 18669648
S1856 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
N1875 N-Glycosylation GlyGen 29391424
S1877 Phosphorylation PhosphoSitePlus
K1917 Acetylation PhosphoSitePlus
S1970 Phosphorylation PhosphoSitePlus
S1973 Phosphorylation PhosphoSitePlus
S1975 Phosphorylation PhosphoSitePlus
S1977 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 18220336
K2048 Acetylation PhosphoSitePlus
N2280 N-Glycosylation GlyGen 29391424
S2333 Phosphorylation PhosphoSitePlus
T2338 Phosphorylation PhosphoSitePlus
Y2364 Phosphorylation PhosphoSitePlus
Y2381 Phosphorylation PhosphoSitePlus
T2433 Phosphorylation PhosphoSitePlus
S2440 Phosphorylation PhosphoSitePlus
S2474 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N1240 N-Glycosylation PRO 29671580
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 18702456
S266 Phosphorylation PhosphoSitePlus
S288 Phosphorylation HPRD 19664994
S525 Phosphorylation HPRD 18510355
S541 Phosphorylation HPRD 18510355
S571 Phosphorylation HPRD 20068231
S576 Phosphorylation HPRD 20068231
S578 Phosphorylation HPRD 20068231
S589 Phosphorylation HPRD 20068231
S1036 Phosphorylation HPRD 19664994
S1168 Phosphorylation HPRD 18669648
Y1179 Phosphorylation HPRD 18669648
S1257 Phosphorylation HPRD 18669648
S1278 Phosphorylation HPRD 18669648
S1296 Phosphorylation HPRD 18669648, 19664994
T1298 Phosphorylation HPRD 19664994
S1342 Phosphorylation HPRD 18669648
S1349 Phosphorylation HPRD 18669648
S1353 Phosphorylation HPRD 18669648
S1457 Phosphorylation HPRD 18669648
S1460 Phosphorylation HPRD 17081983
S1461 Phosphorylation HPRD 18669648, 17081983
S1465 Phosphorylation HPRD 18669648, 17081983
T1522 Phosphorylation HPRD 18669648
S1536 Phosphorylation HPRD 18669648
S1549 Phosphorylation HPRD 20068231
S1557 Phosphorylation HPRD 20068231
T1566 Phosphorylation HPRD 18669648
S1568 Phosphorylation HPRD 18669648
S1603 Phosphorylation PhosphoSitePlus
S1647 Phosphorylation HPRD 17081983
S1798 Phosphorylation HPRD 18669648
S1800 Phosphorylation HPRD 18669648
S1919 Phosphorylation HPRD 19664995
S1921 Phosphorylation HPRD 18669648, 16964243, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 18702456
S288 Phosphorylation HPRD 19664994
S525 Phosphorylation HPRD 18510355
S541 Phosphorylation HPRD 18510355
S571 Phosphorylation HPRD 20068231
S576 Phosphorylation HPRD 20068231
S578 Phosphorylation HPRD 20068231
S589 Phosphorylation HPRD 20068231
S1036 Phosphorylation HPRD 19664994
S1168 Phosphorylation HPRD 18669648
Y1179 Phosphorylation HPRD 18669648
S1257 Phosphorylation HPRD 18669648
S1278 Phosphorylation HPRD 18669648
S1296 Phosphorylation HPRD 18669648, 19664994
T1298 Phosphorylation HPRD 19664994
S1342 Phosphorylation HPRD 18669648
S1349 Phosphorylation HPRD 18669648
S1353 Phosphorylation HPRD 18669648
S1457 Phosphorylation HPRD 18669648
S1460 Phosphorylation HPRD 17081983
S1461 Phosphorylation HPRD 18669648, 17081983
S1465 Phosphorylation HPRD 18669648, 17081983
T1522 Phosphorylation HPRD 18669648
S1536 Phosphorylation HPRD 18669648
S1549 Phosphorylation HPRD 20068231
S1557 Phosphorylation HPRD 20068231
T1566 Phosphorylation HPRD 18669648
S1568 Phosphorylation HPRD 18669648
S1647 Phosphorylation HPRD 17081983
S1795 Phosphorylation HPRD 18669648
S1797 Phosphorylation HPRD 18669648
S1916 Phosphorylation HPRD 19664995
S1918 Phosphorylation HPRD 18669648, 16964243, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N137 S137 Biomuta DOID:1324 / lung cancer [ cosmic ]
N137 T137 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y315 H315 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R496 L496 Biomuta DOID:1324 / lung cancer [ cosmic ]
R496 W496 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
R496 Q496 Biomuta DOID:363 / uterine cancer [ icgc ]
S578 R578 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, cosmic, icgc, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S633 F633 Biomuta DOID:4159 / skin cancer [ cosmic ]
N784 S784 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y906 F906 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y915 N915 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1008 P1008 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1015 L1015 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1036 C1036 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T1075 M1075 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1104 F1104 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1104 Y1104 Biomuta DOID:1319 / brain cancer [ icgc ]
S1113 F1113 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1113 P1113 Biomuta DOID:1612 / breast cancer [ icgc ]
S1115 T1115 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1121 G1121 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1135 K1135 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1190 A1190 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1232 C1232 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1232 Y1232 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1245 T1245 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1287 F1287 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1296 F1296 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1319 F1319 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1342 L1342 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1365 L1365 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1388 F1388 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1538 F1538 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1549 Y1549 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1558 N1558 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1568 N1568 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1591 N1591 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1613 F1613 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N1784 S1784 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1799 P1799 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1799 F1799 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1877 P1877 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1877 F1877 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1917 R1917 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1917 T1917 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1970 F1970 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2338 I2338 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y2364 F2364 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2433 A2433 Biomuta DOID:4159 / skin cancer [ cosmic ]