iPTMnet Report for Q8IVH8 (MAP4K3)
Protein Information
| UniProt AC / UniProt ID | Q8IVH8 / M4K3_HUMAN |
| Protein Name | Mitogen-activated protein kinase kinase kinase kinase 3 |
| Gene Name | Name: MAP4K3 Synonyms:RAB8IPL1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8IVH8 |
| PRO Name | mitogen-activated protein kinase kinase kinase kinase 3 (human) |
| Definition | A mitogen-activated protein kinase kinase kinase kinase 3 that is encoded in the genome of human. |
| Short Label | hMAP4K3 |
| Category | organism-gene |
DAG ViewQ8IVH8 (MAP4K3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378, 22223895 | ||
| S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T26 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y27 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y31 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K32 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T145 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S158 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T164 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K167 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S170 | Phosphorylation | Q8IVH8 (MAP4K3) | score3 | PhosphoSitePlus RLIMS-P Signor | 20227368 | |
| S280 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T327 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S329 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y366 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y367 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y379 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y387 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K397 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S398 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S422 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S467 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S507 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K530 | Acetylation | score1 | PhosphoSitePlus | |||
| S533 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T539 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K541 | Acetylation | score1 | PhosphoSitePlus | |||
| Y574 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S616 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S618 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S661 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y735 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S743 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S893 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y366 | Phosphorylation | score1 | PhosphoSitePlus |
Q8IVH8 (MAP4K3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q04759 (PRKCQ) | T538 | score3 | neXtProt PhosphoSitePlus Signor | 21983831 | |
| Q8IVH8 (MAP4K3) | S170 | score3 | PhosphoSitePlus Signor | 20227368 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y27 | C27 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K32 | E32 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| T145 | M145 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S170 | F170 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y367 | H367 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S533 | T533 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K541 | E541 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S661 | F661 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S893 | I893 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
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