iPTMnet Report for Q8IVF5 (TIAM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVF5 / TIAM2_HUMAN
Protein Name Rho guanine nucleotide exchange factor TIAM2
Gene Name Name: TIAM2
Synonyms:KIAA2016,STEF;
Organism Homo sapiens (Human)

PRO ID PR:Q8IVF5
DAG View
PRO Name Rho guanine nucleotide exchange factor TIAM2 (human)
Definition A Rho guanine nucleotide exchange factor TIAM2 that is encoded in the genome of human.
Short Label hTIAM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVF5 (TIAM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K69 Methylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
T837 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
Y850 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
T1444 Phosphorylation PhosphoSitePlus
K1448 Ubiquitination PhosphoSitePlus
K1480 Methylation PhosphoSitePlus
T1544 Phosphorylation PhosphoSitePlus
S1569 Phosphorylation PhosphoSitePlus
S1583 Phosphorylation PhosphoSitePlus
T1642 Phosphorylation PhosphoSitePlus
S1658 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S700 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S149 T149 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S149 F149 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S298 F298 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y322 H322 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1254 M1254 Biomuta DOID:3571 / liver cancer [ cosmic ]