iPTMnet Report for Q8IVE3 (PLEKHH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IVE3 / PKHH2_HUMAN
Protein Name Pleckstrin homology domain-containing family H member 2
Gene Name Name: PLEKHH2
Synonyms:KIAA2028;
Organism Homo sapiens (Human)

PRO ID PR:Q8IVE3
DAG View
PRO Name pleckstrin homology domain-containing family H member 2 (human)
Definition A pleckstrin homology domain-containing family H member 2 that is encoded in the genome of human.
Short Label hPLEKHH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IVE3 (PLEKHH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S209 O-Glycosylation GlyGen 30379171
K226 Methylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
T636 Phosphorylation PhosphoSitePlus
S641 O-Glycosylation GlyGen 30379171
S641 Phosphorylation PhosphoSitePlus
Y709 Phosphorylation PhosphoSitePlus
Y839 Phosphorylation PhosphoSitePlus
Y840 Phosphorylation PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
T1208 Phosphorylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
Y1300 Phosphorylation PhosphoSitePlus
T1399 Phosphorylation PhosphoSitePlus
T1421 Phosphorylation PhosphoSitePlus
S1458 Phosphorylation PhosphoSitePlus
S1477 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S459 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 F22 Biomuta DOID:4159 / skin cancer [ cosmic ]
T271 S271 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S353 F353 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S549 F549 Biomuta DOID:4159 / skin cancer [ cosmic ]
S565 Y565 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S622 F622 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y839 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S869 L869 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1222 L1222 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]