iPTMnet Report for Q8IV53 (DENND1C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IV53 / DEN1C_HUMAN
Protein Name DENN domain-containing protein 1C
Gene Name Name: DENND1C
Synonyms:FAM31C;
Organism Homo sapiens (Human)

PRO ID PR:Q8IV53
DAG View
PRO Name DENN domain-containing protein 1C (human)
Definition A DENN domain-containing protein 1C that is encoded in the genome of human.
Short Label hDENND1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IV53 (DENND1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C21 Methylation IEDB 31844290
K50 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
T250 Phosphorylation IEDB 32387766
K319 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
R477 Methylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus   UniProt 24275569
S573 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K50 T50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S180 C180 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K319 T319 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K449 E449 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R477 K477 Biomuta DOID:4159 / skin cancer [ cosmic ]
S619 F619 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]