Protein Information

Cytoscape View

UniProt AC / UniProt ID Q8IUQ4 / SIAH1_HUMAN
Protein Name E3 ubiquitin-protein ligase SIAH1
Gene Name Name: SIAH1
Organism Homo sapiens (Human)

DAG View
PRO Name E3 ubiquitin-protein ligase SIAH1 (human)
Definition An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human.
Short Label hSIAH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q8IUQ4 (SIAH1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T13 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K15 Ubiquitination PhosphoSitePlus
S19 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18536714
T70 Phosphorylation PhosphoSitePlus   RLIMS-P 25391652
T74 Phosphorylation PhosphoSitePlus   RLIMS-P 25391652
K89 Acetylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus   RLIMS-P 16230351
Y126 Phosphorylation PhosphoSitePlus   RLIMS-P 16230351
K216 Ubiquitination PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus   RLIMS-P 25391652
T239 Phosphorylation PhosphoSitePlus   RLIMS-P 25391652
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18669648
T13 Phosphorylation HPRD 18669648
Y100 Phosphorylation PRO 9482736, 16230351
Y126 Phosphorylation PRO 9482736, 16230351
Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation PhosphoSitePlus
S33 Phosphorylation HPRD 18669648
T42 Phosphorylation PhosphoSitePlus
T44 Phosphorylation HPRD 18669648


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025641 (hSIAH1/iso:1/Phos:1) pY100,pY126 PRO 16230351, 9482736

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025641 (hSIAH1/iso:1/Phos:1) increased Interaction PR:Q69ZI1-1 (mSH3RF1/iso:1) PRO 16230351
PR:000045369 (hSIAH1/iso:1/UnPhos:1) Interaction PR:Q69ZI1 (mSH3RF1) PRO 16230351
PR:Q69ZI1-1 (mSH3RF1/iso:1) Interaction PR:000025641 (hSIAH1/iso:1/Phos:1) PRO 16230351
PR:Q69ZI1-1 (mSH3RF1/iso:1) Interaction PR:Q8IUQ4 (hSIAH1) PRO 16230351