iPTMnet Report for Q8IUQ4 (SIAH1)
Protein Information
| UniProt AC / UniProt ID | Q8IUQ4 / SIAH1_HUMAN |
| Protein Name | E3 ubiquitin-protein ligase SIAH1 |
| Gene Name | Name: SIAH1 Synonyms:HUMSIAH; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8IUQ4 |
| PRO Name | E3 ubiquitin-protein ligase SIAH1 (human) |
| Definition | An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human. |
| Short Label | hSIAH1 |
| Category | organism-gene |
DAG ViewQ8IUQ4 (SIAH1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T13 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| T13 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K15 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S19 | Phosphorylation | Q13535 (ATR) , Q13315 (ATM) | score3 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 18536714 | |
| T70 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25391652 | ||
| T74 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25391652 | ||
| K89 | Acetylation | score1 | PhosphoSitePlus | |||
| Y100 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 16230351 | ||
| Y126 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 16230351 | ||
| K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T235 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25391652 | ||
| T239 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25391652 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T13 | Phosphorylation | score0 | HPRD | 18669648 | ||
| Y100 | Phosphorylation | score3 | PRO | 9482736, 16230351 | ||
| Y126 | Phosphorylation | score3 | PRO | 9482736, 16230351 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S33 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T42 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T44 | Phosphorylation | score0 | HPRD | 18669648 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000025641 (hSIAH1/iso:1/Phos:1) | pY100,pY126 | PRO | 16230351, 9482736 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000025641 (hSIAH1/iso:1/Phos:1) | increased Interaction | PR:Q69ZI1-1 (mSH3RF1/iso:1) | PRO | 16230351 | |
| PR:000045369 (hSIAH1/iso:1/UnPhos:1) | Interaction | PR:Q69ZI1 (mSH3RF1) | PRO | 16230351 | |
| PR:Q69ZI1-1 (mSH3RF1/iso:1) | Interaction | PR:000025641 (hSIAH1/iso:1/Phos:1) | PRO | 16230351 | |
| PR:Q69ZI1-1 (mSH3RF1/iso:1) | Interaction | PR:Q8IUQ4 (hSIAH1) | PRO | 16230351 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T70 | I70 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T74 | I74 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] |
