iPTMnet Report for Q8IUC6 (TICAM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IUC6 / TCAM1_HUMAN
Protein Name TIR domain-containing adapter molecule 1
Gene Name Name: TICAM1
Synonyms:PRVTIRB,TRIF;
Organism Homo sapiens (Human)

PRO ID PR:Q8IUC6
DAG View
PRO Name TIR domain-containing adapter molecule 1 (human)
Definition A TIR domain-containing adapter molecule 1 that is encoded in the genome of human.
Short Label hTICAM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IUC6 (TICAM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K65 Ubiquitination PhosphoSitePlus
C109 Methylation IEDB 31844290
S196 Phosphorylation HPRD 20068231
S199 Phosphorylation HPRD   PhosphoSitePlus 18669648
S205 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus   UniProt 27302953, 25636800
S212 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S223 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S212 C212 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S223 I223 Biomuta DOID:1324 / lung cancer [ cosmic ]
K707 R707 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]