iPTMnet Report for Q8IU68 (TMC8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IU68 / TMC8_HUMAN
Protein Name Transmembrane channel-like protein 8
Gene Name Name: TMC8
Synonyms:EVER2,EVIN2;
Organism Homo sapiens (Human)

PRO ID PR:Q8IU68
DAG View
PRO Name transmembrane channel-like protein 8 (human)
Definition A transmembrane channel-like protein 8 that is encoded in the genome of human.
Short Label hTMC8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IU68 (TMC8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S522 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K630 Ubiquitination PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus   UniProt 23186163
S666 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S722 Phosphorylation IEDB   PhosphoSitePlus 33936100
Site PTM Type PTM Enzyme Score Source PMID
S522 Phosphorylation HPRD 17081983
S656 Phosphorylation HPRD 20058876
S658 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S522 W522 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S522 L522 Biomuta DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S656 N656 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S683 Y683 Biomuta DOID:4159 / skin cancer [ cosmic ]
S683 F683 Biomuta DOID:4159 / skin cancer [ cosmic ]
S703 F703 Biomuta DOID:9256 / colorectal cancer [ cosmic ]