iPTMnet Report for Q8IU60 (DCP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8IU60 / DCP2_HUMAN
Protein Name m7GpppN-mRNA hydrolase
Gene Name Name: DCP2
Synonyms:NUDT20;
Organism Homo sapiens (Human)

PRO ID PR:Q8IU60
DAG View
PRO Name m7GpppN-mRNA hydrolase (human)
Definition An m7GpppN-mRNA hydrolase that is encoded in the genome of human.
Short Label hDCP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8IU60 (DCP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K85 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
C207 Methylation IEDB 31844290
T213 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
S246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S247 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S249 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26098573, 21406692, 23186163, ...18669648
S254 Phosphorylation PhosphoSitePlus
S276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S284 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648, ...19690332, 20068231
K291 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
K312 Methylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K314 Methylation PhosphoSitePlus
R319 Methylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S246 Phosphorylation HPRD 19651622, 18669648, 17081983
S247 Phosphorylation HPRD 19651622, 18669648, 17081983
S249 Phosphorylation HPRD 19651622, 18669648, 17081983
S276 Phosphorylation HPRD 17525332
S284 Phosphorylation HPRD 19651622, 17525332, 18669648, ...20068231
S347 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K85 I85 Biomuta DOID:1324 / lung cancer [ cosmic ]
K154 E154 Biomuta DOID:3571 / liver cancer [ cosmic ]
K204 E204 Biomuta DOID:363 / uterine cancer [ icgc ]
T213 P213 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S246 F246 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y326 H326 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S375 P375 Biomuta DOID:1319 / brain cancer [ cosmic ]
S376 G376 Biomuta DOID:3571 / liver cancer [ cosmic ]