iPTMnet Report for Q8C863 (Itch)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8C863 / ITCH_MOUSE
Protein Name E3 ubiquitin-protein ligase Itchy
Gene Name Name: Itch
Organism Mus musculus (Mouse)

PRO ID PR:Q8C863
DAG View
PRO Name E3 ubiquitin-protein ligase Itchy (mouse)
Definition An E3 ubiquitin-protein ligase Itchy that is encoded in the genome of mouse.
Short Label mITCH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8C863 (Itch) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S199 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32513985, 16446428
S199 Phosphorylation Q91Y86 (Mapk8) phospho.ELM 16446428
T222 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32513985, 16446428
T222 Phosphorylation Q91Y86 (Mapk8) phospho.ELM 16446428
S232 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32513985, 16446428
S232 Phosphorylation Q91Y86 (Mapk8) phospho.ELM 16446428
K311 Ubiquitination PhosphoSitePlus
Y381 Phosphorylation Signor 16387660
Y381 Phosphorylation P39688 (Fyn) Signor 16387660
K393 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
T425 Phosphorylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8C863 (Itch) T222 Q9JJP2 (Tp73) increased_association eFIP 32513985