iPTMnet Report for Q8BUN5 (Smad3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8BUN5 / SMAD3_MOUSE
Protein Name Mothers against decapentaplegic homolog 3
Gene Name Name: Smad3
Synonyms:Madh3;
Organism Mus musculus (Mouse)

PRO ID PR:Q8BUN5
DAG View
PRO Name mothers against decapentaplegic homolog 3 (mouse)
Definition A smad3 that is encoded in the genome of mouse.
Short Label mSMAD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8BUN5 (Smad3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation RLIMS-P 27221338
T8 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
C121 S-Nitrosylation dbSNO 21278135
T132 Phosphorylation PhosphoSitePlus
T179 Phosphorylation RLIMS-P 30132832, 26289811, 21295571, ...25945408, 22045334, 24391884
S204 Phosphorylation PhosphoSitePlus   RLIMS-P 30132832, 26289811, 33232327
S208 Phosphorylation RLIMS-P 30132832, 24391884, 21295571, ...26289811
S213 Phosphorylation PhosphoSitePlus   RLIMS-P 29234059, 25945408, 30132832, ...26289811
S309 Phosphorylation PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
S422 Phosphorylation UniProt 9380693
S423 Phosphorylation Q64729 (Tgfbr1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19458083, 9380693, 30132832, ...27207538, 26289811, 29581148, 23786998, 33232327
S425 Phosphorylation Q64729 (Tgfbr1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19458083, 9380693, 30132832, ...27207538, 33232327, 29581148, 23786998, 26289811
Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PRO 15241418
T179 Phosphorylation PRO 15241418, 10197981
S204 Phosphorylation PRO 10197981
S208 Phosphorylation PRO 10197981
S213 Phosphorylation PRO 15241418, 10197981
S423 Phosphorylation PRO 9702197, 12943993, 15282343, ...10823886, 15464984
S425 Phosphorylation PRO 9702197, 12943993, 15282343, ...10823886, 15464984


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036558 (mSMAD3/iso:1/Phos:1) pS423,pS425 PRO 10823886, 12943993, 15282343, ...15464984, 9702197
PR:000036560 (mSMAD3/iso:1/Phos:2) pT8,pT179,pS213 PRO 15241418
PR:000036561 (mSMAD3/iso:1/Phos:3) pT179,pS204,pS208,pS213 PRO 10197981


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8BUN5 (Smad3) T179 A2A5Z6 (Smurf2) increased_association eFIP 22045334


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q8BUN5-1 (mSMAD3/iso:1) Interaction PR:A2A8R0 (mZFYVE9/iso:1) PRO 12154125
PR:Q8BUN5-1 (mSMAD3/iso:1) Interaction PR:000036434 (mTGFBR1/iso:1/SigPep-/Phos:1) PRO 12154125