iPTMnet Report for Q86YV5 (PRAG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86YV5 / PRAG1_HUMAN
Protein Name Inactive tyrosine-protein kinase PRAG1
Gene Name Name: PRAG1
Synonyms:SGK223;
Organism Homo sapiens (Human)

PRO ID PR:Q86YV5
DAG View
PRO Name inactive tyrosine-protein kinase PRAG1 (human)
Definition An inactive tyrosine-protein kinase PRAG1 that is encoded in the genome of human.
Short Label hSGK223
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86YV5 (PRAG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y159 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
Y413 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 16497976
S416 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S510 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T517 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S653 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S668 Phosphorylation PhosphoSitePlus
K686 Acetylation PhosphoSitePlus
K693 Acetylation PhosphoSitePlus
S694 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S696 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T710 Phosphorylation PhosphoSitePlus
S712 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S729 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S745 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S747 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S782 Phosphorylation PhosphoSitePlus   UniProt 24275569
T784 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S827 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
T842 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
Y864 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S879 Phosphorylation PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
T1227 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S135 C135 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S146 A146 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y159 H159 Biomuta DOID:4159 / skin cancer [ cosmic ]
T160 I160 Biomuta [ cosmic ]
S234 L234 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S270 F270 Biomuta DOID:4159 / skin cancer [ cosmic ]
S275 F275 Biomuta DOID:4159 / skin cancer [ cosmic ]
S285 L285 Biomuta [ cosmic ]
S313 R313 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y365 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S495 C495 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T517 I517 Biomuta DOID:1324 / lung cancer [ cosmic ]
S610 Y610 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S651 G651 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S745 R745 Biomuta DOID:1612 / breast cancer [ cosmic ]
S747 F747 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S776 L776 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S805 A805 Biomuta DOID:1324 / lung cancer [ cosmic ]
S827 L827 Biomuta DOID:4159 / skin cancer [ cosmic ]
S852 L852 Biomuta DOID:363 / uterine cancer [ cosmic ]
T854 N854 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y864 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S865 L865 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S867 R867 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S879 F879 Biomuta DOID:4159 / skin cancer [ cosmic ]
S907 N907 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1227 A1227 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2998 / testicular cancer [ cosmic ]