iPTMnet Report for Q86YT6 (MIB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86YT6 / MIB1_HUMAN
Protein Name E3 ubiquitin-protein ligase MIB1
Gene Name Name: MIB1
Synonyms:DIP1,KIAA1323,ZZANK2;
Organism Homo sapiens (Human)

PRO ID PR:Q86YT6
DAG View
PRO Name E3 ubiquitin-protein ligase MIB1 (human)
Definition An E3 ubiquitin-protein ligase MIB1 that is encoded in the genome of human.
Short Label hMIB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86YT6 (MIB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K202 Acetylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus   UniProt 24275569
S411 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
K896 Ubiquitination PhosphoSitePlus
K917 Ubiquitination PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
K949 Ubiquitination PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
S990 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 N28 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K79 N79 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y376 C376 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K452 E452 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K691 N691 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K749 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K826 N826 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S990 C990 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]