iPTMnet Report for Q86YR7 (MCF2L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86YR7 / MF2L2_HUMAN
Protein Name Probable guanine nucleotide exchange factor MCF2L2
Gene Name Name: MCF2L2
Synonyms:ARHGEF22,DRG,KIAA0861;
Organism Homo sapiens (Human)

PRO ID PR:Q86YR7
DAG View
PRO Name probable guanine nucleotide exchange factor MCF2L2 (human)
Definition A probable guanine nucleotide exchange factor MCF2L2 that is encoded in the genome of human.
Short Label hMCF2L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86YR7 (MCF2L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K255 Ubiquitination PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
K435 Methylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T630 Phosphorylation PhosphoSitePlus
Y751 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
K900 Acetylation PhosphoSitePlus
K901 Acetylation PhosphoSitePlus
K904 Acetylation PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
T1017 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S426 F426 Biomuta DOID:4159 / skin cancer [ cosmic ]
S437 N437 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S437 C437 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S449 F449 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S774 C774 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S774 F774 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1017 N1017 Biomuta DOID:2531 / hematologic cancer [ cosmic ]