Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86YN6 / PRGC2_HUMAN
Protein Name Peroxisome proliferator-activated receptor gamma coactivator 1-beta
Gene Name Name: PPARGC1B
Synonyms:PERC,PGC1,PGC1B,PPARGC1;
Organism Homo sapiens (Human)

PRO ID PR:Q86YN6
DAG View
PRO Name peroxisome proliferator-activated receptor gamma coactivator 1-beta (human)
Definition A peroxisome proliferator-activated receptor gamma coactivator 1-beta that is encoded in the genome of human.
Short Label hPPARGC1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86YN6 (PPARGC1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation RLIMS-P 23300015
S239 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus   UniProt 23186163
S524 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S570 Phosphorylation P31749 (AKT1) neXtProt 17554339
S638 Phosphorylation PhosphoSitePlus   UniProt 23186163
S643 Phosphorylation PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
Y943 Phosphorylation PhosphoSitePlus
T947 Phosphorylation PhosphoSitePlus
Y948 Phosphorylation PhosphoSitePlus
Y987 Phosphorylation PhosphoSitePlus
Y990 Phosphorylation PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S133 F133 Biomuta DOID:1612 / breast cancer [ tcga ]
S263 F263 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S854 * Biomuta DOID:1115 / sarcoma [ tcga ]
S856 C856 Biomuta DOID:1793 / pancreatic cancer [ tcga ]