Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86YC2 / PALB2_HUMAN
Protein Name Partner and localizer of BRCA2
Gene Name Name: PALB2
Synonyms:FANCN;
Organism Homo sapiens (Human)

PRO ID PR:Q86YC2
DAG View
PRO Name partner and localizer of BRCA2 (human)
Definition A partner and localizer of BRCA2 that is encoded in the genome of human.
Short Label hPALB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86YC2 (PALB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S64 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 28089683
S145 Phosphorylation PhosphoSitePlus
S157 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 26420486
S172 Phosphorylation PhosphoSitePlus   UniProt 23186163
S190 Phosphorylation PhosphoSitePlus   UniProt 23186163
S201 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus   UniProt 23186163
S288 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K307 Acetylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S376 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 18077418, ...26420486, 20068231
K379 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S387 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18452278, 19690332, 20068231
S390 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus   UniProt 23186163
S488 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
S660 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 15302935, 19664994, ...23186163
T757 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus   UniProt 23186163
S792 Phosphorylation PhosphoSitePlus
Y1055 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
T1167 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q86YC2 (PALB2) S64 P38398 (BRCA1) inhibited_association eFIP 28858227


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S157 L157 Biomuta DOID:0070003 / blastoma [ cosmic ]
S190 L190 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S201 N201 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K294 N294 Biomuta DOID:3070 / malignant glioma [ tcga ]
K295 T295 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K307 T307 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S357 Y357 Biomuta DOID:363 / uterine cancer [ tcga ]
K379 N379 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S488 I488 Biomuta DOID:1612 / breast cancer [ clinvar, cosmic, icgc ]
S489 F489 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S518 * Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S1165 L1165 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]