iPTMnet Report for Q86Y46 (KRT73)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86Y46 / K2C73_HUMAN
Protein Name Keratin, type II cytoskeletal 73
Gene Name Name: KRT73
Synonyms:K6IRS3,KB36,KRT6IRS3;
Organism Homo sapiens (Human)

PRO ID PR:Q86Y46
DAG View
PRO Name keratin, type II cytoskeletal 73 (human)
Definition A keratin, type II cytoskeletal 73 that is encoded in the genome of human.
Short Label hKRT73
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86Y46 (KRT73) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K344 Acetylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
R444 Methylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y417 Phosphorylation HPRD 19664994, 20068231
S422 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K142 N142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K142 M142 Biomuta DOID:4159 / skin cancer [ cosmic ]
S188 G188 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T230 K230 Biomuta DOID:3571 / liver cancer [ cosmic ]
K436 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S502 T502 Biomuta DOID:9256 / colorectal cancer [ cosmic ]