Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86Y37 / CACL1_HUMAN
Protein Name CDK2-associated and cullin domain-containing protein 1
Gene Name Name: CACUL1
Synonyms:C10orf46,CAC1;
Organism Homo sapiens (Human)

PRO ID PR:Q86Y37
DAG View
PRO Name CDK2-associated and cullin domain-containing protein 1 (human)
Definition A CDK2-associated and cullin domain-containing protein 1 that is encoded in the genome of human.
Short Label hCACUL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86Y37 (CACUL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S118 O-Glycosylation GlyGen 29351928
K186 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
C362 S-Nitrosylation dbSNO 26338901
R366 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K239 M239 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K330 T330 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R366 S366 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]