iPTMnet Report for Q86Y37 (CACUL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86Y37 / CACL1_HUMAN
Protein Name CDK2-associated and cullin domain-containing protein 1
Gene Name Name: CACUL1
Synonyms:C10orf46,CAC1;
Organism Homo sapiens (Human)

PRO ID PR:Q86Y37
DAG View
PRO Name CDK2-associated and cullin domain-containing protein 1 (human)
Definition A CDK2-associated and cullin domain-containing protein 1 that is encoded in the genome of human.
Short Label hCACUL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86Y37 (CACUL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S118 O-Glycosylation GlyGen 31492838, 29351928, 35132862, ...35254053, 31373491, 29237092
T119 O-Glycosylation GlyGen 31492838, 29351928, 35132862, ...35254053
K186 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
C362 S-Nitrosylation dbSNO 26338901
R366 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S118 A118 Biomuta DOID:3571 / liver cancer [ cosmic ]
K239 M239 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K330 T330 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R366 S366 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]