Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86Y07 / VRK2_HUMAN
Protein Name Serine/threonine-protein kinase VRK2
Gene Name Name: VRK2
Organism Homo sapiens (Human)

PRO ID PR:Q86Y07
DAG View
PRO Name serine/threonine-protein kinase VRK2 (human)
Definition A serine/threonine-protein kinase VRK2 that is encoded in the genome of human.
Short Label hVRK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86Y07 (VRK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus   UniProt 18691976
S339 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus   UniProt 23186163
K419 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation phospho.ELM 18669648
T437 Phosphorylation phospho.ELM 18669648
S438 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K443 Methylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T336 Phosphorylation HPRD 18691976
S339 Phosphorylation HPRD 18691976
Y430 Phosphorylation HPRD 18669648
T437 Phosphorylation HPRD 18691976, 18669648, 20068231
S438 Phosphorylation HPRD 18669648
S445 Phosphorylation HPRD 18691976


Q86Y07 (VRK2) as PTM Enzyme



Substrate Site Score Source PMID
O75531 (BANF1) T2 PhosphoSitePlus   Signor 16495336
O75531 (BANF1) T3 PhosphoSitePlus   Signor 16495336
O75531 (BANF1) S4 neXtProt   PhosphoSitePlus   Signor 16371512, 16495336, 20511217
P04637 (TP53) T18 neXtProt 16704422
P38432 (COIL) S184 neXtProt   PhosphoSitePlus 21920476
Q13469 (NFATC2) S31 Signor 23105117
Q9UHP3 (USP25) T680 PhosphoSitePlus 25755282
Q9UHP3 (USP25) T727 PhosphoSitePlus 25755282
Q9UHP3 (USP25) S745 PhosphoSitePlus 25755282


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K93 E93 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K177 N177 Biomuta DOID:363 / uterine cancer [ tcga ]
K223 N223 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K443 Q443 Biomuta DOID:3571 / liver cancer [ tcga ]
S445 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S449 C449 Biomuta DOID:5041 / esophageal cancer [ icgc ]