iPTMnet Report for Q86Y07 (VRK2)
Protein Information
| UniProt AC / UniProt ID | Q86Y07 / VRK2_HUMAN |
| Protein Name | Serine/threonine-protein kinase VRK2 |
| Gene Name | Name: VRK2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q86Y07 |
| PRO Name | serine/threonine-protein kinase VRK2 (human) |
| Definition | A serine/threonine-protein kinase VRK2 that is encoded in the genome of human. |
| Short Label | hVRK2 |
| Category | organism-gene |
DAG ViewQ86Y07 (VRK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K10 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K33 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y44 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K75 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K93 | Acetylation | score1 | PhosphoSitePlus | |||
| K112 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K177 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C194 | Methylation | score1 | IEDB | 31844290 | ||
| K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K311 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K328 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T336 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976 | ||
| S339 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S369 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K377 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K383 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K402 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S406 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K419 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y430 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| T437 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| S438 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K443 | Methylation | score1 | PhosphoSitePlus | |||
| K443 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S445 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S449 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T336 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S339 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y430 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T437 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 | ||
| S438 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S445 | Phosphorylation | score0 | HPRD | 18691976 |
Q86Y07 (VRK2) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O75531 (BANF1) | T2 | score3 | PhosphoSitePlus Signor | 16495336 | |
| O75531 (BANF1) | T3 | score3 | PhosphoSitePlus Signor | 16495336 | |
| O75531 (BANF1) | S4 | score4 | neXtProt PhosphoSitePlus Signor | 16371512, 16495336, 20511217 | |
| P04637 (TP53) | T18 | score2 | neXtProt | 16704422 | |
| P38432 (COIL) | S184 | score3 | neXtProt PhosphoSitePlus | 21920476 | |
| Q13469 (NFATC2) | S31 | score1 | Signor | 23105117 | |
| Q9UHP3 (USP25) | T680 | score3 | PhosphoSitePlus Signor | 25755282 | |
| Q9UHP3 (USP25) | T727 | score3 | PhosphoSitePlus Signor | 25755282 | |
| Q9UHP3 (USP25) | S745 | score3 | PhosphoSitePlus Signor | 25755282 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K93 | E93 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K139 | R139 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| K177 | N177 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K223 | N223 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K255 | R255 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K328 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T336 | S336 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K443 | Q443 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S445 | * | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S447 | F447 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S449 | C449 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] |
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