iPTMnet Report Q86XR7 TICAM2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q86XR7 / TCAM2_HUMAN
Protein Name	TIR domain-containing adapter molecule 2
Gene Name	Name: TICAM2 Synonyms:TIRAP3,TIRP,TRAM;
Organism	Homo sapiens (Human)

PRO ID	PR:Q86XR7 DAG View
PRO Name	TIR domain-containing adapter molecule 2 (human)
Definition	A TIR domain-containing adapter molecule 2 that is encoded in the genome of human.
Short Label	hTICAM2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q86XR7 (TICAM2) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	G2	Myristoylation		score2	UniProt	16603631
	S14	Phosphorylation		score1	PhosphoSitePlus
	S16	Phosphorylation	Q02156 (PRKCE)	score3	neXtProt PhosphoSitePlus RLIMS-P Signor UniProt	16757566
	S22	Phosphorylation		score1	PhosphoSitePlus
	Y167	Phosphorylation		score2	UniProt	25825441

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	G2	Myristoylation		score2	PRO	16757566
	S16	Phosphorylation		score2	PRO	16757566

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K46	Ubiquitination		score1	PhosphoSitePlus
	Y50	Phosphorylation		score1	PhosphoSitePlus
	K83	Ubiquitination		score1	PhosphoSitePlus
	K87	Ubiquitination		score1	PhosphoSitePlus
	K91	Ubiquitination		score1	PhosphoSitePlus
	Y164	Phosphorylation		score1	PhosphoSitePlus
	K204	Acetylation		score1	PhosphoSitePlus
	K205	Acetylation		score1	PhosphoSitePlus

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000027201 (hTICAM2/iso:1/InitMet-/Myr:1)	myG2		PRO
	PR:000040891 (hTICAM2/iso:1/InitMet-/MyrPhos:1)	pS16		PRO	16757566
	PR:000040891 (hTICAM2/iso:1/InitMet-/MyrPhos:1)	myG2		PRO	16757566

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S14	F14	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]