iPTMnet Report for Q86XF0 (DHFR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86XF0 / DYR2_HUMAN
Protein Name Dihydrofolate reductase 2, mitochondrial
Gene Name Name: DHFR2
Synonyms:DHFRL1,DHFRP4;
Organism Homo sapiens (Human)

PRO ID PR:Q86XF0
DAG View
PRO Name dihydrofolate reductase 2, mitochondrial (human)
Definition A dihydrofolate reductase 2, mitochondrial that is encoded in the genome of human.
Short Label hDHFR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86XF0 (DHFR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R33 Methylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 N56 Biomuta DOID:1324 / lung cancer [ cosmic ]
K64 N64 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T137 A137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y163 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K179 N179 Biomuta DOID:9256 / colorectal cancer [ cosmic ]