iPTMnet Report for Q86X95 (CIR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86X95 / CIR1_HUMAN
Protein Name Corepressor interacting with RBPJ 1
Gene Name Name: CIR1
Synonyms:CIR;
Organism Homo sapiens (Human)

PRO ID PR:Q86X95
DAG View
PRO Name corepressor interacting with RBPJ 1 (human)
Definition A corepressor interacting with RBPJ 1 that is encoded in the genome of human.
Short Label hCIR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86X95 (CIR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Methylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
C143 Methylation IEDB 31844290
K182 Methylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
K340 Sumoylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
Y429 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S202 Phosphorylation HPRD 17322306, 18669648, 20058876, ...19664995, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 N65 Biomuta DOID:4159 / skin cancer [ cosmic ]
S343 N343 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S344 F344 Biomuta DOID:4159 / skin cancer [ cosmic ]
S351 I351 Biomuta DOID:1324 / lung cancer [ cosmic ]
S351 G351 Biomuta DOID:1324 / lung cancer [ cosmic ]
S353 F353 Biomuta DOID:1612 / breast cancer [ cosmic ]
S365 I365 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S394 R394 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S397 I397 Biomuta DOID:2531 / hematologic cancer [ cosmic ]