iPTMnet Report for Q86WB0 (ZC3HC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86WB0 / ZC3C1_HUMAN
Protein Name Zinc finger C3HC-type protein 1
Gene Name Name: ZC3HC1
Synonyms:NIPA;ORFNames:HSPC216;
Organism Homo sapiens (Human)

PRO ID PR:Q86WB0
DAG View
PRO Name zinc finger C3HC-type protein 1 (human)
Definition A zinc finger C3HC-type protein 1 that is encoded in the genome of human.
Short Label hZC3HC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86WB0 (ZC3HC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
S24 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231, 17081983
T28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...17081983
K31 Ubiquitination PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S62 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 15302935, ...19690332
K75 Ubiquitination PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus   UniProt 21851590, 23186163
T84 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S87 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
C102 Methylation IEDB 31844290
Y105 Phosphorylation phospho.ELM 12748172
Y105 Phosphorylation Q9UM73 (ALK) phospho.ELM 12748172
Y137 Phosphorylation phospho.ELM 12748172
Y137 Phosphorylation Q9UM73 (ALK) phospho.ELM 12748172
K146 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
C190 Methylation IEDB 31844290
S321 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 18220336, 18669648, 24275569, 20068231, 17081983
S329 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
T333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S335 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S344 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 27920218, ...18669648, 24275569, 19690332, 20068231
S350 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T352 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S354 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...18220336, 12748172, 27226629, 15302935, 18669648, 24275569, 22955283, 19690332
S354 Phosphorylation P27361 (MAPK3) neXtProt 22955283
S354 Phosphorylation P28482 (MAPK1) neXtProt 22955283
S357 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S358 Phosphorylation PhosphoSitePlus
S359 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22955283, 18669648, 27226629, ...19690332
S359 Phosphorylation P27361 (MAPK3) neXtProt 22955283
S359 Phosphorylation P28482 (MAPK1) neXtProt 22955283
R363 Methylation PhosphoSitePlus
S370 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
T372 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus   UniProt 23186163
T384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S394 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18847512
S394 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S395 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 18220336, 18847512, ...27226629, 18234856, 18669648, 17389604, 19690332
S395 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 17389604, 18234856
S395 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 17389604, 18847512
S407 Phosphorylation PhosphoSitePlus   UniProt 24275569
S408 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus   UniProt 23186163
K485 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation HPRD 17322306, 18767875, 19664995, ...19651622, 18669648, 20068231
T28 Phosphorylation HPRD 17322306, 19413330, 18669648, ...16964243, 20068231
S58 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S62 Phosphorylation HPRD 19413330, 15302935, 19664994, ...19664995, 18452278, 19651622, 15345747, 20068231, 19691289
Y105 Phosphorylation HPRD 12748172
Y137 Phosphorylation HPRD 12748172
S321 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 19651622, 17322306, 18669648, 20068231
S329 Phosphorylation HPRD 16964243, 19691289
T333 Phosphorylation HPRD 18669648
S335 Phosphorylation HPRD 19413330, 17322306, 16964243, ...19664994, 19691289, 19664995, 19651622, 18669648, 20068231
S338 Phosphorylation HPRD 19413330, 18767875, 18669648, ...19664995, 20230923
S344 Phosphorylation HPRD 19413330, 16964243, 20230923, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231, 19691289
S350 Phosphorylation HPRD 18669648
T352 Phosphorylation HPRD 18669648, 20068231
S354 Phosphorylation HPRD 19651622, 18669648, 12748172, ...20068231, 18452278
S357 Phosphorylation HPRD 18669648, 18452278
S358 Phosphorylation HPRD 19651622, 18452278
S359 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S370 Phosphorylation HPRD 19664995, 16964243, 19664994, ...19007248, 18452278, 19651622, 18669648, 20068231
T372 Phosphorylation HPRD 18452278
T373 Phosphorylation HPRD 20068231
T384 Phosphorylation HPRD 18669648
T387 Phosphorylation HPRD 19413330, 18669648
S394 Phosphorylation HPRD 18669648, 19664995, 20068231
S395 Phosphorylation HPRD 19413330, 18691976, 19651622, ...19664995, 18452278, 17322306, 18669648, 20166139, 19415658, 20068231
S407 Phosphorylation HPRD 18212344, 20068231, 19664995
S471 Phosphorylation HPRD 20068231
S472 Phosphorylation HPRD 20068231
T477 Phosphorylation HPRD 20068231
S479 Phosphorylation HPRD 20068231
S481 Phosphorylation HPRD 20068231
S483 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 T24 Biomuta DOID:1324 / lung cancer [ cosmic ]
T52 M52 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S98 C98 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T352 I352 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S354 C354 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S358 F358 Biomuta DOID:4159 / skin cancer [ cosmic ]
R363 H363 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
T372 I372 Biomuta DOID:263 / kidney cancer [ cosmic ]
S381 T381 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S394 C394 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S394 F394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S408 F408 Biomuta DOID:4159 / skin cancer [ cosmic ]
S410 C410 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S411 L411 Biomuta DOID:363 / uterine cancer [ icgc ]
S415 Y415 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S415 F415 Biomuta DOID:4159 / skin cancer [ cosmic ]