iPTMnet Report for Q86W50 (METTL16)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86W50 / MET16_HUMAN
Protein Name RNA N6-adenosine-methyltransferase METTL16
Gene Name Name: METTL16
Synonyms:METT10D;
Organism Homo sapiens (Human)

PRO ID PR:Q86W50
DAG View
PRO Name RNA N6-adenosine-methyltransferase METTL16 (human)
Definition An RNA N6-adenosine-methyltransferase METTL16 that is encoded in the genome of human.
Short Label hMETTL16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86W50 (METTL16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus   UniProt 18691976, 18669648, 23186163
S333 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
T430 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S329 Phosphorylation HPRD 18691976, 18669648
S450 Phosphorylation HPRD 18077418
S453 Phosphorylation HPRD 18077418
S455 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S325 F325 Biomuta DOID:4159 / skin cancer [ cosmic ]
S416 P416 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S453 F453 Biomuta DOID:4159 / skin cancer [ cosmic ]
S455 F455 Biomuta DOID:4159 / skin cancer [ cosmic ]