iPTMnet Report for Q86VY4 (TSPYL5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VY4 / TSYL5_HUMAN
Protein Name Testis-specific Y-encoded-like protein 5
Gene Name Name: TSPYL5
Synonyms:KIAA1750;
Organism Homo sapiens (Human)

PRO ID PR:Q86VY4
DAG View
PRO Name testis-specific Y-encoded-like protein 5 (human)
Definition A testis-specific Y-encoded-like protein 5 that is encoded in the genome of human.
Short Label hTSPYL5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VY4 (TSPYL5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R90 Methylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T120 Phosphorylation HPRD   PhosphoSitePlus 18669648
K133 Ubiquitination PhosphoSitePlus
K148 Acetylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K185 Methylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K307 Acetylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
T409 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...35132862
S414 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...35132862


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S111 Y111 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T120 S120 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K185 R185 Biomuta DOID:1612 / breast cancer [ cosmic ]
K185 N185 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S414 I414 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]