iPTMnet Report for Q86VS8 (HOOK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VS8 / HOOK3_HUMAN
Protein Name Protein Hook homolog 3
Gene Name Name: HOOK3
Organism Homo sapiens (Human)

PRO ID PR:Q86VS8
DAG View
PRO Name protein Hook homolog 3 (human)
Definition A protein Hook homolog 3 that is encoded in the genome of human.
Short Label hHOOK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VS8 (HOOK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
S3 Phosphorylation PhosphoSitePlus   UniProt 23186163
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163
S162 Phosphorylation PhosphoSitePlus
S165 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y171 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S238 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 20068231
S280 Phosphorylation PhosphoSitePlus
S322 Phosphorylation HPRD 20068231
S366 Phosphorylation PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S494 Phosphorylation HPRD   PhosphoSitePlus 20068231
K546 Acetylation PhosphoSitePlus
K547 Acetylation PhosphoSitePlus
K554 Acetylation PhosphoSitePlus
K564 Acetylation PhosphoSitePlus
R591 Methylation PhosphoSitePlus
Y604 Phosphorylation PhosphoSitePlus
Y607 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
R684 Methylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
T688 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus   UniProt 23186163
S707 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231, ...18220336
Y708 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 W6 Biomuta DOID:1324 / lung cancer [ icgc ]
S6 L6 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S162 Y162 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S232 C232 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K546 Q546 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K564 N564 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R591 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K634 N634 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S646 L646 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y651 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S687 N687 Biomuta DOID:9256 / colorectal cancer [ cosmic ]