iPTMnet Report for Q86VR2 (RETREG3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VR2 / RETR3_HUMAN
Protein Name Reticulophagy regulator 3
Gene Name Name: RETREG3
Synonyms:FAM134C;
Organism Homo sapiens (Human)

PRO ID PR:Q86VR2
DAG View
PRO Name reticulophagy regulator 3 (human)
Definition A reticulophagy regulator 3 that is encoded in the genome of human.
Short Label hRETREG3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VR2 (RETREG3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 20068231
T10 Phosphorylation IEDB   PhosphoSitePlus   UniProt 35494241, 23186163, 20068231
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y49 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
C141 Methylation IEDB 31844290
K220 Ubiquitination PhosphoSitePlus
S229 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y233 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S258 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S260 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S274 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T275 Phosphorylation PhosphoSitePlus
T283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S285 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S288 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S303 Phosphorylation PhosphoSitePlus
T307 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
T310 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S313 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332
S325 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
S360 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S373 Phosphorylation PhosphoSitePlus
S433 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S435 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S436 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T440 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S456 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 20068231
T10 Phosphorylation HPRD 19413330, 18578522, 20068231
S15 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 18578522
Y49 Phosphorylation HPRD 17016520
S229 Phosphorylation HPRD 18669648
S258 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 18452278
S260 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 18452278
S274 Phosphorylation HPRD 18669648
T283 Phosphorylation HPRD 18669648, 17081983
S285 Phosphorylation HPRD 18669648, 17081983
S288 Phosphorylation HPRD 18669648, 17081983
T307 Phosphorylation HPRD 18669648, 17081983
T310 Phosphorylation HPRD 18669648, 17081983
S313 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S320 Phosphorylation HPRD 19651622, 18578522, 18669648, ...20068231, 17081983
S325 Phosphorylation HPRD 17081983, 20068231
S335 Phosphorylation HPRD 20068231
S360 Phosphorylation HPRD 18669648, 19007248
S433 Phosphorylation HPRD 18669648
S435 Phosphorylation HPRD 18669648, 17081983
S436 Phosphorylation HPRD 18669648, 17081983, 18452278
T440 Phosphorylation HPRD 18669648, 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T275 A275 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S288 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S320 R320 Biomuta DOID:4362 / cervical cancer [ icgc ]
S325 F325 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y358 C358 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S360 C360 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S360 F360 Biomuta DOID:3571 / liver cancer [ cosmic ]
S433 F433 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]