Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VP6 / CAND1_HUMAN
Protein Name Cullin-associated NEDD8-dissociated protein 1
Gene Name Name: CAND1
Synonyms:KIAA0829,TIP120,TIP120A;
Organism Homo sapiens (Human)

PRO ID PR:Q86VP6
DAG View
PRO Name cullin-associated NEDD8-dissociated protein 1 (human)
Definition A cullin-associated NEDD8-dissociated protein 1 that is encoded in the genome of human.
Short Label hCAND1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VP6 (CAND1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
S3 Phosphorylation PhosphoSitePlus
Y6 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K55 Acetylation PhosphoSitePlus   UniProt 19608861
K55 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
S335 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
S340 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K355 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus   UniProt 23186163
C571 S-Nitrosylation dbSNO 19483679
K574 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K586 Acetylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
T624 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T670 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
Y796 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
K957 Ubiquitination PhosphoSitePlus
K971 Acetylation PhosphoSitePlus   UniProt 19608861
Y973 Phosphorylation PhosphoSitePlus
S976 Phosphorylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
Y980 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
K1005 Ubiquitination PhosphoSitePlus
C1007 S-Nitrosylation dbSNO 22178444
K1037 Ubiquitination PhosphoSitePlus
R1082 Methylation PhosphoSitePlus
C1134 S-Nitrosylation dbSNO 19483679
K1168 Acetylation PhosphoSitePlus
K1168 Ubiquitination PhosphoSitePlus
K1173 Acetylation PhosphoSitePlus
S1175 Phosphorylation PhosphoSitePlus
K1191 Acetylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
S1226 Phosphorylation PhosphoSitePlus
T1229 Phosphorylation PhosphoSitePlus
S1230 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 20068231
T16 Phosphorylation HPRD 20068231
S107 Phosphorylation HPRD 20068230
S295 Phosphorylation HPRD 20058876
T296 Phosphorylation HPRD 20058876
S335 Phosphorylation HPRD 18691976, 18669648
S340 Phosphorylation HPRD 18691976, 18669648
S866 Phosphorylation HPRD 20068231
Y980 Phosphorylation HPRD 18452278
S984 Phosphorylation HPRD 18452278
T992 Phosphorylation HPRD 18452278
S1219 Phosphorylation HPRD 20068231
T1229 Phosphorylation HPRD 19651622


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q13616-1 (hCUL1/iso:1) Interaction PR:Q86VP6-1 (hCAND1/iso:1) PRO 12504026, 15537541


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T16 A16 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S38 F38 Biomuta DOID:363 / uterine cancer [ tcga ]
S107 G107 Biomuta DOID:3070 / malignant glioma [ tcga ]
S558 L558 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:1115 / sarcoma [ tcga ]
K577 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S591 F591 Biomuta DOID:1909 / melanoma [ tcga ]
S638 P638 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K801 N801 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S828 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y980 H980 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y980 C980 Biomuta DOID:263 / kidney cancer [ cosmic ]
K1005 N1005 Biomuta DOID:363 / uterine cancer [ tcga ]
R1082 T1082 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1175 Y1175 Biomuta DOID:4362 / cervical cancer [ tcga ]
S1220 L1220 Biomuta DOID:1324 / lung cancer [ cosmic ]